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Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients. | LitMetric
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Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients.

Anne P J de Pagter Lianne M Haveman Rob Schuurman Martin Schutten Marc Bierings Jaap-Jan Boelens

Clin Infect Dis

Department of Pediatric Immunology and Hematology, Wilhelmina Children's Hospital Utrecht, Utrecht, the Netherlands.

Published: November 2009

Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.

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http://dx.doi.org/10.1086/644739DOI Listing

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