An asymmetric Diels-Alder reaction between acrolein and 1-benzyloxymethyl-1,3-cyclohexadiene affords a bicyclic aldehyde that was elaborated in 11 steps to nor-platencin. nor-Platencin is 4-16 times less active than platencin against several resistant strains of Staphylococcus aureus, macrolide-resistant Enterococcus faecalis, and vancomycin-resistant Enterococcus faecium.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789445 | PMC |
| http://dx.doi.org/10.1021/ol902194q | DOI Listing |
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