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Case report: anti-IgLON5 disease combined with paraneoplastic cerebellar degeneration with the detection of anti-sulfatide IgG antibody, masquerading as meningoencephalitis.
BMC Neurol
December 2024
Department of Neurology, Guangdong Sanjiu Brain Hospital, Guangzhou, Guangdong, China.
Objective: Anti-IgLON5 disease is a rare autoimmune mediated disease. It is mainly featured by sleep-related disturbance, parkinsonism, chorea and limb ataxia. Previous studies had clarified its clinical manifestations and predisposing genes.
View Article and Find Full Text PDFUltrarare Cause of Childhood Chorea: Celiac Disease.
J Child Neurol
December 2024
Department of Pediatric Neurology, Ankara Etlik City Hospital, Ankara, Turkey.
Introduction: Chorea, a movement disorder that commonly affects children, may be caused by various diseases with metabolic, structural, pharmacologic, or autoimmune origins. Celiac disease is an autoimmune enteropathy that may rarely cause neurologic symptoms in children, primarily ataxia and peripheral neuropathy, even in the absence of gastrointestinal symptoms.
Case Report: A 9-year-old male patient diagnosed with Sydenham chorea was admitted to our clinic because of valproic acid resistance.
The Spectrum of Movement Disorders Associated with Systemic Lupus Erythematosus.
Curr Neurol Neurosci Rep
November 2024
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Purpose Of Review: This review seeks to examine the prevalence, pathophysiology, diagnostic challenges, and treatment strategies for movement disorders in patients with systemic lupus erythematosus (SLE).
Recent Findings: In recent years, the spectrum and number of autoimmune movement disorders has rapidly expanded with the identification of neuronal and paraneoplastic antibodies which should be considered in the differential for patients with acute to subacute development of a movement disorder. The identification of SLE in a patient with a new onset movement disorder may lead to earlier treatment with immune therapies especially if other systemic manifestations are present.
A Case Report of an Atypical Presentation of Morvan Syndrome.
Cureus
September 2024
Internal Medicine, California Hospital Medical Center, Los Angeles, USA.
Article Synopsis
- Morvan syndrome, or Morvan's fibrillary chorea, is a rare neurological condition linked to cancer, showing symptoms that affect the CNS, peripheral nerves, and autonomic functions.
- A case study highlighted an adult female who suddenly experienced chest pain, weakness, and muscle spasms, revealing positive VGKC and amphiphysin antibodies in her blood.
- The diagnosis of Morvan syndrome involves recognizing myokymia, positive VGKC antibodies, and neuropsychiatric symptoms, with this case demonstrating a unique link to amphiphysin positivity.
Paraneoplastic neurological syndromes of small cell lung cancer.
Postep Psychiatr Neurol
June 2024
Department of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Purpose: This article reviews the relevant literature on paraneoplastic neurological syndromes of small cell lung cancer and discusses the clinical presentation, pathophysiology, and diagnosis of these syndromes. It also includes a summary of the current treatment options for the management of them.
Views: Paraneoplastic syndromes are a group of signs and symptoms that develop due to cancer in a remote site, mainly triggered by an autoantibody produced by the tissues involved or lymphocytes during anti-cancer defense.
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