MRI contrast agent delivery using spore capsules: controlled release in blood plasma.

Chem Commun (Camb)

Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.

Published: November 2009

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.

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http://dx.doi.org/10.1039/b909551aDOI Listing

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