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A conserved cysteine in the DNA-binding domain of MmuPV1 E2 is required for replication .
J Virol
December 2024
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Unlabelled: The papillomavirus (PV) E2 protein is highly conserved, consisting of an N-terminal transactivation domain linked to a C-terminal DNA binding and dimerization domain (DBD) by a flexible hinge region. The E2 DBD exhibits a helix-turn-helix structure that dimerizes into a beta barrel prior to binding DNA; the first helix, α1, is responsible for recognition of the palindromic E2 binding site. The DNA recognition helix consists of a tract of basic amino acids with a highly conserved central cysteine residue.
View Article and Find Full Text PDFCase report: The use of metagenomic next-generation sequencing to diagnose Lemierre's syndrome caused by lost root canal fillings in a 33-year-old patient with metabolic syndrome.
Front Med (Lausanne)
August 2024
Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Article Synopsis
- * A case involving a 33-year-old male with fever and sore throat revealed thrombosis in the jugular vein after a recent dental issue, leading to a diagnosis of Lemierre's syndrome.
- * The case emphasizes the importance of considering Lemierre's syndrome in patients with similar symptoms, especially if they have a history of dental issues, and highlights the utility of metagenomic next-generation sequencing (mNGS) for difficult diagnoses.
Impact of Modified Diet, Swallowing Exercises, and Electrostimulation on Quality of Life of Older Patients Suffering from Oropharyngeal Dysphagia.
Medicina (Kaunas)
June 2024
Clinical Department of Geriatrics, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
: Oropharyngeal dysphagia is defined as a swallowing disorder in which it becomes difficult to form a bolus and move food from the mouth to the proximal part of the esophagus. Several factors can cause this disorder in geriatric patients. With oropharyngeal dysphagia, the patient's social isolation and the risk of depression increase, while the quality of life deteriorates.
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