Point-of-care testing for disasters: needs assessment, strategic planning, and future design.

Clin Lab Med

Department of Pathology and Laboratory Medicine, UC Davis-LLNL Point-of-Care Technologies Center [NIBIB, NIH], Point-of-Care Testing Center for Teaching and Research (POCT*CTR), School of Medicine, University of California, Davis, CA 95616, USA.

Published: September 2009

Objective evidence-based national surveys serve as a first step in identifying suitable point-of-care device designs, effective test clusters, and environmental operating conditions. Preliminary survey results show the need for point-of-care testing (POCT) devices using test clusters that specifically detect pathogens found in disaster scenarios. Hurricane Katrina, the tsunami in southeast Asia, and the current influenza pandemic (H1N1, "swine flu") vividly illustrate lack of national and global preparedness. Gap analysis of current POCT devices versus survey results reveals how POCT needs can be fulfilled. Future thinking will help avoid the worst consequences of disasters on the horizon, such as extensively drug-resistant tuberculosis and pandemic influenzas. A global effort must be made to improve POC technologies to rapidly diagnose and treat patients to improve triaging, on-site decision making, and, ultimately, economic and medical outcomes.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115727PMC
http://dx.doi.org/10.1016/j.cll.2009.07.014DOI Listing

Publication Analysis

Top Keywords

point-of-care testing
8
test clusters
8
poct devices
8
testing disasters
4
disasters assessment
4
assessment strategic
4
strategic planning
4
planning future
4
future design
4
design objective
4

Similar Publications

Pen direct writing of multiplex-LFIA for detection of thiamphenicol and tylosin in milk.

Mikrochim Acta

January 2025

Tyndall National Institute, University College Cork, Lee Maltings Complex, Dyke Parade, Cork, T12R5CP, Ireland.

Therapeutic and misuse of veterinary drugs, such as antibiotics, can increase the potential risk of residue contamination in animal-derived food products. For milk, these residual antibiotics can have an impact on efficiency in dairy processing factories, as well as economic loss, and can also cause side effects on consumer health. Lateral flow immunoassays (LFIAs) are gaining popularity for their ease of use, low cost and their fulfilment to the REASSURED (real-time connection/monitoring, easy sampling, affordable, specific, user-friendly, rapid/robust, equipment free, deliverable to end user) criteria.

View Article and Find Full Text PDF

Background: Studies on the accuracy of point-of-care (POC) testing using capillary samples are scarce. Therefore, this study aimed to assess the analytical accuracy of POC testing for white blood cell (WBC) and C-reactive protein (CRP) using capillary samples compared with conventional central laboratory testing using venous samples in a pediatric ambulatory care setting.

Methods: This was a retrospective study including patients younger than 18 years who underwent concurrent WBC and CRP evaluations via capillary and subsequent venous sampling within a 2-h window.

View Article and Find Full Text PDF

Recent advances in centrifugal microfluidics for point-of-care testing.

Lab Chip

January 2025

The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

Point-of-care testing (POCT) holds significant importance in the field of infectious disease prevention and control, as well as personalized precision medicine. The emerging microfluidics, capable of minimal reagent consumption, integration, and a high degree of automation, play a pivotal role in POCT. Centrifugal microfluidics, also termed lab-on-a-disc (LOAD), is a significant subfield of microfluidics that integrates crucial analytical steps onto a single chip, thereby optimizing the process and enabling high-throughput, automated analysis.

View Article and Find Full Text PDF

Amplification-free CRISPR/Cas based dual-enzymatic colorimetric nucleic acid biosensing device.

Lab Chip

January 2025

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

Nucleic acid testing (NAT) is widely considered the gold standard in analytical fields, with applications spanning environmental monitoring, forensic science and clinical diagnostics, among others. However, its widespread use is often constrained by complicated assay procedures, the need for specialized equipment, and the complexity of reagent handling. In this study, we demonstrate a fully integrated 3D-printed biosensensing device employing a CRISPR/Cas12a-based dual-enzymatic mechanism for highly sensitive and user-friendly nucleic acid detection.

View Article and Find Full Text PDF

Community pharmacies: Key players in point-of-care diagnostics for STI screening in Africa.

PLoS One

January 2025

Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Background: Sexually Transmitted Infections (STIs) rank in the top 5 disease categories for which adults in developing countries seek healthcare services. Community pharmacies offer clients convenience, proximity, extended opening hours, privacy, and efficiency, which could make them desirable locations for HIV and STI screening and treatment. We examined the feasibility of using point-of-care (POC) STI tests for screening HIV and other STIs at community pharmacies.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!