AI Article Synopsis
- DNA methylation is a reversible process that plays a crucial role in regulating gene expression and genomic stability, particularly during mammalian development.
- The methylation of CpG islands leads to transcriptional silencing, which is significant for cell growth, differentiation, and is linked to cancer development.
- Demethylation therapy shows promise in treating blood cancers that resist traditional treatments, by restoring the function of anti-oncogenes and has been researched for various hematological malignancies like leukemia and lymphoma.
Article Abstract
DNA methylation is an important and reversible epigenetic modification which regulates genomic stability. Methylation is essential for mammalian development. Generally, gene expression level and DNA methylation are negative correlation. Transcriptional silencing via methylation of CpG islands in the promoter is important for cell growth and differentiation and plays a key role in tumorigenesis. Demethylation drug can modify chromatin and restore the ability of anti-oncogene. Demethylation therapy as a new therapy may treat efficiently hematological malignancies with resistance and relapse. In this review, DNA methylation mechanism, relationship between aberrant methylation and hematologic malignancies, mechanism of demethylation therapy, the advance of research on the demethylation therapy of hematological malignancies, such as acute and chronic leukemia, lymphoma, myelodysplastic syndrome were summarized.
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