Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1651-2227.2009.01555.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Differential Effects of Prenatal Buprenorphine and Methadone on Postnatal Growth and Gene Expression in the Nucleus Accumbens.
Dev Psychobiol
January 2025
Department of Comparative Pathobiology, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Article Synopsis
- Methadone and buprenorphine are used during pregnancy to help women with opioid use disorder, but babies exposed to these medications may experience neonatal opioid withdrawal syndrome (NOWS), affecting their feeding behavior.
- A study involving pregnant female rats showed that offspring exposed to either drug had lower weights compared to those given saline, with buprenorphine offspring maintaining lower weights longer than those exposed to methadone.
- Gene expression analysis indicated that while both drugs had similar effects, methadone-exposed offspring exhibited significantly reduced levels of the gene proopiomelanocortin (Pomc), suggesting different developmental impacts between the two medications.
Effects of prenatal exposure to methadone or buprenorphine and maternal separation on anxiety-like behavior in rats.
Drug Alcohol Depend
September 2024
Section of Forensic Research, Department of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, Oslo 0424, Norway; Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, P.O. Box 1068 Blindern, Oslo 0316, Norway.
Background: The use of medications for opioid use disorder such as methadone or buprenorphine is increasing among pregnant women. However, long-term effects of this treatment on the children's health are not well understood. A key challenge is distinguishing the effects of opioid exposure from other confounding factors associated with human opioid use, such as reduced maternal care.
View Article and Find Full Text PDFPrenatal and postnatal factors associated with sudden infant death syndrome: an umbrella review of meta-analyses.
World J Pediatr
May 2024
Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
Background: Comprehensive quantitative evidence on the risk and protective factors for sudden infant death syndrome (SIDS) effects is lacking. We investigated the risk and protective factors related to SIDS.
Methods: We conducted an umbrella review of meta-analyses of observational and interventional studies assessing SIDS-related factors.
Fetal and Infant Effects of Maternal Opioid Use during Pregnancy: A Literature Review including Clinical, Toxicological, Pharmacogenomic, and Epigenetic Aspects for Forensic Evaluation.
Children (Basel)
February 2024
Unit of Legal Medicine, Department of Medical and Surgical Sciences, University of Bologna, Via Irnerio 49, 40126 Bologna, Italy.
The two primary classes of opioid substances are morphine and its synthetic derivative, heroin. Opioids can cross the placental barrier, reaching fetal circulation. Therefore, at any gestational age, the fetus is highly exposed to pharmacologically active opioid metabolites and their associated adverse effects.
View Article and Find Full Text PDFMethadone administered to rat dams during pregnancy and lactation affects the circadian rhythms of their pups.
J Neurosci Res
November 2023
Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic.
The circadian clock is one of the most important homeostatic systems regulating the majority of physiological functions. Its proper development contributes significantly to the maintenance of health in adulthood. Methadone is recommended for the treatment of opioid use disorders during pregnancy, increasing the number of children prenatally exposed to long-acting opioids.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!