A 2(3) factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration (c) and relative density of tablet (d) on the disintegration time (DT) and dissolution times, t1, t50 and t90, of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization of starch binders on these parameters, i.e., N, c and d. In general, the most common ranking of the individual effects on DT, t1, t50 and t90 for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations was c > d > N. For interaction effects, the most common ranking was N-c > c-d > N-d for all formulations. The results generally showed that c can considerably affect DT, t1, t50 and t90 of the tablets.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2478/v10007-007-0006-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Catalytic performance of Pd catalyst supported on CeO or ZrO modified beta zeolite for methane oxidation.
J Environ Sci (China)
June 2025
School of Rare Earths, University of Science and Technology of China, Hefei 230026, China; Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341000, China; State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Two kinds of oxide-zeolite composite support, Ce-beta and Zr-beta were prepared by a simple wet impregnation method and adopted for the preparation of palladium-based catalysts for catalytic oxidation of methane. The Pd/6.8Zr-beta catalyst showed superior methane oxidation performance, achieving T and T of 417 °C and 451 °C, respectively, together with robust hydrothermal stability.
View Article and Find Full Text PDFInsight into catalytic performance and reaction mechanism for toluene total oxidation over Cu-Ce supported catalyst.
J Environ Sci (China)
March 2025
School of Environment and Energy, South China University of Technology, Guangzhou 510006, China; National Engineering Laboratory for VOCs Pollution Control Technology and Equipment, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, South China University of Technology, Guangzhou 510006, China; Guangdong Provincial Engineering and Technology Research Centre for Environmental Risk Prevention and Emergency Disposal, South China University of Technology, Guangzhou 510006, China. Electronic address:
Herein, three supported catalysts, CuO/AlO, CeO/AlO, and CuO-CeO/AlO, were synthesized by the convenient impregnation method to reveal the effect of CeO addition on catalytic performance and reaction mechanism for toluene oxidation. Compared with CuO/AlO, the T and T (the temperatures at 50% and 90% toluene conversion, respectively) of CuO-CeO/AlO were reduced by 33 and 39 °C, respectively. N adsorption-desorption experiment, XRD, SEM, EDS mapping, Raman, EPR, H-TPR, O-TPD, XPS, NH-TPD, Toluene-TPD, and in-situ DRIFTS were conducted to characterize these catalysts.
View Article and Find Full Text PDFBamboo-like MnO⋅CoO: High-performance catalysts for the oxidative removal of toluene.
J Environ Sci (China)
January 2025
Beijing Key Laboratory for Green Catalysis and Separation, Key Laboratory of Beijing on Regional Air Pollution Control, Key Laboratory of Advanced Functional Materials, Education Ministry of China, Laboratory of Catalysis Chemistry and Nanoscience, Department of Chemical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China. Electronic address:
The manganese-cobalt mixed oxide nanorods were fabricated using a hydrothermal method with different metal precursors (KMnO and MnSO·HO for MnO and Co(NO)⋅6HO and CoCl⋅6HO for CoO). Bamboo-like MnO⋅CoO (B-MnO⋅CoO (S)) was derived from repeated hydrothermal treatments with CoO@MnO and MnSO⋅HO, whereas CoO@MnO nanorods were derived from hydrothermal treatment with CoO nanorods and KMnO. The study shows that manganese oxide was tetragonal, while the cobalt oxide was found to be cubic in the crystalline arrangement.
View Article and Find Full Text PDFLess Is More: Selective-Atom-Removal-Derived Defective MnO Catalyst for Efficient Propane Oxidation.
Nanomaterials (Basel)
May 2024
State Key Laboratory of BioFibers and Eco-Textiles, Institute of Materials for Energy and Environment, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.
Defect manipulation in metal oxide is of great importance in boosting catalytic performance for propane oxidation. Herein, a selective atom removal strategy was developed to construct a defective manganese oxide catalyst, which involved the partial etching of a Mg dopant in MnO. The resulting MgMnO-H catalysts exhibited superior low-temperature catalytic activity (T = 185 °C, T = 226 °C) with a propane conversion rate of 0.
View Article and Find Full Text PDFFabrication and optimization of extended-release beads of diclofenac sodium based on Ca cross-linked Taro (Colocasia esculenta) stolon polysaccharide and pectin by quality-by-design approach.
Int J Biol Macromol
June 2024
Department of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur, Dist., Darjeeling, West Bengal 734013, India. Electronic address:
The present investigation was aimed to fabricate and optimize extended-release beads of diclofenac sodium based on an ion-cross-linked matrix of pectin (PTN) and taro (Colocasia esculenta) stolon polysaccharide (TSP) with 2 full factorial design. Total polysaccharide concentration (TPC), polysaccharide ratio (PR), and cross-linker concentration ([CaCl]) were taken as independent factors with two levels of each. Initially, TSP was extracted, purified, and characterized.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!