Objective: To present our experience in head and neck cancer, and the development of our own local electronic Makkah Head and Neck Database.
Methods: A prospective collection of cases was conducted between October 2007 and November 2008 of patients diagnosed with head and neck cancer within the Department of Otolaryngology, Head and Neck Surgery at Al-Noor Specialist Hospital, Makkah, Kingdom of Saudi Arabia.
Results: Forty-four patients were included in this study. There were 24 males (54.5%), and 20 females (45.5%). Sixteen patients (36.4%) had oral cavity cancer, 10 patients (22.7%) had hypopharyngeal cancer, 10 patients (22.7%) had nasopharyngeal cancer, 6 patients (13.6%) had thyroid cancer, and 2 patients (4.5%) had neck secondary-unknown primary. Thirty-six patients (81.8%) presented with stages III and IV versus 8 patients (18.1%) with stages I and II (p=0.0016). Twenty-four patients (54.5%) were managed primarily by surgery, while 20 patients (45.5%) were managed primarily non-surgically in the form of external beam radiotherapy (XRT), or XRT/Chemotherapy. Outcomes were: 16 patients (38%) were free of any recurrence, 2 patients (5%) died in the perioperative period, 2 patients (5%) had loco-regional recurrence, and 24 patients (54%) were lost follow up.
Conclusion: All oncological services of head and neck cancer patients including surgery, radiotherapy, and chemotherapy should be provided in one oncology center, and managed through a standard one channel, namely, the Head and Neck Oncology Board, to achieve standard patient care, adequate follow up, and surveillance.
Download full-text PDF |
Source |
---|
Genome Med
January 2025
Otology & Neurotology Group CTS495, Instituto de Investigación Biosanitario, Ibs.GRANADA, Universidad de Granada, 18071, Granada, Spain.
Background: Familial Meniere's disease (FMD) is a rare polygenic disorder of the inner ear. Mutations in the connexin gene family, which encodes gap junction proteins, can also cause hearing loss, but their role in FMD is largely unknown.
Methods: We retrieved exome sequencing data from 94 individuals in 70 Meniere's disease (MD) families.
Diagn Pathol
January 2025
Department of Diagnostic Pathology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Background: Perivascular epithelioid cell tumors (PEComas) rarely appear in the head and neck region. This case report describes two transcription factor E3 (TFE3)-rearranged PEComa cases, consisting of one in the orbit and one in the nasal cavity.
Case Presentation: Both cases demonstrated sheet-like or focal nested architecture and comprised epithelioid cells with abundant clear to eosinophilic cytoplasm and vascular stroma.
BMC Cancer
January 2025
Department of Otorhinolaryngology, Shenzhen Key Laboratory of Otorhinolaryngology, Longgang Otorhinolaryngology Hospital, Shenzhen Institute of Otorhinolaryngology, No. 3004 Longgang Avenue, Shenzhen, Guangdong, China.
Background: To investigate the role of the translocase of the outer mitochondrial membrane 40 (TOM40) in oral squamous cell carcinoma (OSCC) with the aim of identifying new biomarkers or potential therapeutic targets.
Methods: TOM40 expression level in OSCC was evaluated using datasets downloaded from The Cancer Genome Atlas (TCGA), as well as clinical data. The correlation between TOM40 expression level and the clinicopathological parameters and survival were analyzed in TCGA.
Psychooncology
January 2025
School of Nursing, Hunan Normal University, Changsha, China.
Background: Postoperative patients with oral cancer are deeply distressed about their body image. However, their true inner feelings and the factors influencing body image remain unclear.
Aims: This study aims to investigate the experience of body image disturbance in patients 3 months after oral cancer surgery and analyze the influencing factors.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!