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Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations. | LitMetric
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Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations.

James McNulty Jerald J Nair Endreddy Bollareddy Kunal Keskar Amol Thorat Denis J Crankshaw Alison C Holloway Ghaznia Khan Gerard D Wright Linda Ejim

Phytochemistry

Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4M1.

Published: December 2009

An investigation of the constituents in heartwood and resin of Prunus avium is reported. A mini-library of structurally diverse flavanones and flavones was screened for human cytochrome P450 1A1, 3A4 and 19 (aromatase) inhibition, and for antifungal activity against a panel of pathogenic fungi. The defensive role of these natural plant flavonoids as antifungal phytoalexins and phytoanticipins is discussed.

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http://dx.doi.org/10.1016/j.phytochem.2009.08.018DOI Listing

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