Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.earlhumdev.2009.09.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular insights into myelomeningocele via proteomic analysis of amniotic fluid.
J Proteomics
January 2025
Necker Proteomics, Université Paris Cité - Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR3633, Paris, France.
Despite numerous studies on fetal therapy for myelomeningoceles (MMC), the pathophysiology of this malformation remains poorly understood. This study aimed to analyze the biochemical profile and proteome of amniotic fluid (AF) supernatants from MMC fetuses to explore the prenatal pathophysiology. Biochemical analysis of 61 AF samples from MMC fetuses was compared with 45 healthy fetuses' samples.
View Article and Find Full Text PDFInterplay Between Vitamin D Levels and Heavy Metals Exposure in Pregnancy and Childbirth: A Systematic Review.
Pathophysiology
November 2024
Área Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca P.O. Box 42160, Hidalgo, Mexico.
Article Synopsis
- Vitamin D deficiency in pregnant women is linked to higher risks of gestational disorders that can impact both the mother's and baby's health.
- Recent research investigates how toxic elements like heavy metals interact with vitamin D levels during pregnancy.
- A review of selected studies suggests that maintaining adequate vitamin D levels may help reduce the harmful effects of heavy metal exposure, which could lower the chances of pregnancy complications such as preterm birth.
Role of Amniotic Fluid Toxicity in the Pathophysiology of Myelomeningocele: A Narrative Literature Review.
Prenat Diagn
November 2024
Department of Fetal Medicine, Armand Trousseau Hospital, AP-HP, DMU ORIGYNE, National Reference Center for Rare Disease: Spin@, Sorbonne University, Paris, France.
Myelomeningocele is a birth defect whose clinical manifestations are due both to incomplete neural tube closure and the progressive destruction of exposed neuroepithelium during pregnancy. Two hypotheses have been formulated to explain the spinal cord damage in utero: mechanical trauma and chemical factors. The objective of this review was to summarize the current insights about the potential role of amniotic fluid in spinal cord damage in myelomeningocele.
View Article and Find Full Text PDFA neonatal mouse model of meconium peritonitis generated using human meconium slurry.
Pediatr Res
August 2024
Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Background: Meconium peritonitis is a noninfectious chemical peritonitis that occurs following fetal intestinal perforation and leakage of meconium into the abdominal cavity. Because of the lack of appropriate animal models, its pathophysiology has not yet been elucidated. We aimed to create a neonatal mouse model of meconium peritonitis using human meconium slurry (MS).
View Article and Find Full Text PDFDo maternal BMI and gestational weight gain equally affect the risk of infant hypoxic and traumatic events?
PLoS One
August 2024
Department of Diagnostic and Clinical Medicine and Public Health, Statistics Unit, University of Modena and Reggio Emilia, Modena, Italy.
Article Synopsis
- Small and large for gestational age (SGA and LGA) infants have higher morbidity risks compared to those appropriate for gestational age (AGA), influenced by maternal factors like pre-pregnancy BMI and gestational weight gain (GWG).
- A study analyzed data from 110,594 mother-infant pairs to determine how these maternal factors affected infant health outcomes, particularly hypoxic and traumatic morbidities.
- Results indicated that overweight and obese mothers had a significantly increased risk of hypoxic morbidity in infants, especially when GWG exceeded recommendations, while traumatic morbidity was more common in obese mothers.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!