The progressive increase of prevalence and incidence of dementia require growing attention in identifying subjects with early cognitive impairment. We have evaluated the results of mini mental state examination (MMSE) and CDT in elderly patients affected by MCI and mild dementia and in subjects without cognitive impairment, to measure whether combined use of two well-known cognitive screening tests (MMSE, CDT) is useful to identify precociously subjects with possible MCI. Using the statistical model of binomial logistic regression we have pointed out that CDT better differentiates healthy controls from MCI patients. MMSE, on the contrary of CDT, differentiates MCI patients from subjects affected by dementia. Finally, during screening, administration of both CDT and MMSE can be useful to identify precociously subjects with possible MCI.
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http://dx.doi.org/10.1016/j.archger.2009.09.033 | DOI Listing |
BMC Psychiatry
January 2025
School of Mental Health, Bengbu Medical University, Bengbu, Anhui, 233030, China.
Background: Although impaired cognitive control is common during the acute detoxification phase of substance use disorders (SUD) and is considered a major cause of relapse, it remains unclear after prolonged methadone maintenance treatment (MMT). The aim of the present study was to elucidate cognitive control in individuals with heroin use disorder (HUD) after prolonged MMT and its association with previous relapse.
Methods: A total of 63 HUD subjects (41 subjects with previous relapse and 22 non-relapse subjects, mean MMT duration: 12.
Mol Neurobiol
January 2025
Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Neuroinflammation has been acknowledged as being one of the main pathologies that occur following chronic cerebral hypoperfusion (CCH). Since it significantly contributes to neuronal cell damage and thereby leads to cognitive impairment, the signals related to inflammation in hypoperfusion injury have been extensively investigated over the past few years. Toll-like receptor 4 (TLR4) is the key receptor responsible for immune and inflammatory reactions.
View Article and Find Full Text PDFMol Neurobiol
January 2025
School of Pharmacy, Chengdu Medical College, Chengdu, 610500, PR China.
Alzheimer's disease (AD) is a prominent neurodegenerative disorder affecting the central nervous system in the elderly. Current understanding of AD primarily centers on the gradual decline in cognitive and memory functions, believed to be influenced by factors including mitochondrial dysfunction, β-amyloid aggregation, and neuroinflammation. Emerging research indicates that neuroinflammation plays a significant role in the development of AD, with the inflammasome potentially mediating inflammatory responses that contribute to neurodegeneration.
View Article and Find Full Text PDFMol Neurobiol
January 2025
Radiation Biotechnology Department, Institute of Nuclear Medicine and Allied Sciences (INMAS), Defence Research and Development Organization (DRDO), Brig. S.K. Mazumdar Road, Timarpur, Delhi, 110054, India.
Gamma radiation is known to induce several detrimental effects on the nervous system. The hippocampus region, specifically the dentate gyrus (DG) and subventricular zone (SVZ), have been identified as a radiation-sensitive neurogenic niche. Radiation alters the endogenous redox status of neural stem cells (NSCs) and other proliferative cells, especially in the hippocampus region, leading to oxidative stress, neuroinflammation, and cell death.
View Article and Find Full Text PDFCurr Nutr Rep
January 2025
School of Medical, Indigenous and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong NSW, Wollongong, 2522, Australia.
Purpose Of The Review: Clinical trials suggest that dietary anthocyanins may enhance cognitive function. This systematic literature review and meta-analysis aimed to identify the effect of anthocyanin on cognition and mood in adults.
Recent Findings: Using a random-effects model, Hedge's g scores were calculated to estimate the effect size.
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