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We Must Consider Infrastructure when Attempting to Scale up Autism EBIs: A Case Example from Early Intervention Systems.
Adm Policy Ment Health
November 2024
Henry Ford Health, Center for Health Policy and Health Services Research, Detroit, MI, USA.
In the autism field, there is increasing interest in translating evidence-based interventions (EBIs) into systems that serve young autistic children and their families. Public Early Intervention systems have been a focal point of research-based implementation efforts given that these systems are federally mandated to provide services to children birth to three years of age with developmental delays under Part C of the Individuals with Disabilities Education Act. Although a growing number of research studies are now training Early Intervention providers to deliver autism EBIs, this work has been conducted on a relatively small scale and has only just begun to consider the alignment of these models with Early Intervention systems and whether sufficient infrastructure exists to scale up these training efforts and to sustain their public health impact.
View Article and Find Full Text PDFAutomated multiconformer model building for X-ray crystallography and cryo-EM.
Elife
June 2024
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.
In their folded state, biomolecules exchange between multiple conformational states that are crucial for their function. Traditional structural biology methods, such as X-ray crystallography and cryogenic electron microscopy (cryo-EM), produce density maps that are ensemble averages, reflecting molecules in various conformations. Yet, most models derived from these maps explicitly represent only a single conformation, overlooking the complexity of biomolecular structures.
View Article and Find Full Text PDFEffects of a Digital Mental Health Intervention on Perceived Stress and Rumination in Adolescents Aged 13 to 17 Years: Randomized Controlled Trial.
J Med Internet Res
March 2024
Twill, New York, NY, United States.
Background: Although adolescents report high levels of stress, they report engaging in few stress management techniques. Consequently, developing effective and targeted programs to help address this transdiagnostic risk factor in adolescence is particularly important. Most stress management programs for adolescents are delivered within schools, and the evidence for these programs is mixed, suggesting a need for alternative options for stress management among adolescents.
View Article and Find Full Text PDFReply to 'skin cancer, photoprotection, and skin of color'.
J Am Acad Dermatol
September 2014
Society Hill Dermatology and Cosmetic Center, Philadelphia, Pennsylvania.
Skin cancer and photoprotection in people of color: a review and recommendations for physicians and the public.
J Am Acad Dermatol
April 2014
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Skin cancer is less prevalent in people of color than in the white population. However, when skin cancer occurs in non-whites, it often presents at a more advanced stage, and thus the prognosis is worse compared with white patients. The increased morbidity and mortality associated with skin cancer in patients of color compared with white patients may be because of the lack of awareness, diagnoses at a more advanced stage, and socioeconomic factors such as access to care barriers.
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