The hemodynamic effects of three commonly used muscle relaxants, pancuronium, vecuronium, and atracurium were investigated during induction of anesthesia with sufentanil and lorazepam in patients undergoing coronary artery bypass surgery. Direct hemodynamic variables were recorded, and indirect parameters were calculated using standard formulae. Changes in heart rate differed with the three muscle relaxants. Pancuronium increased the heart rate whereas vecuronium and atracurium produced a decrease 5 minutes after induction (P less than 0.05). No differences were found in any other parameter during the study. A slow induction with sufentanil, lorazepam, and any of the three muscle relaxants was shown to minimize the hemodynamic changes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0888-6296(90)90042-e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficient Reversal of Neuromuscular Blocking Agent-Induced Biological Functions and Side Effects by an Extended Biphen[3]arene Carboxylate.
J Med Chem
December 2024
State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China.
Article Synopsis
- * A new compound called ExBP3C was developed as an effective reversal agent for multiple NMBAs, showing strong binding capabilities with agents like atracurium and rocuronium.
- * ExBP3C demonstrated better efficiency than the existing reversal drug sugammadex, and in tests, it rapidly corrected heart rate issues caused by an overdose of atracurium within two minutes, indicating good safety and biocompatibility.
The Dosage of Muscle Relaxants in Morbidly Obese Patients in Daily Practice - A Narrative Review.
Int J Gen Med
September 2024
Department of Anaesthesiology and Intensive Care, Regional Specialist Hospital in Olsztyn, Olsztyn, Poland.
The prevalence of morbid obesity in today's population around the world is alarming. Morbid obesity involves substantial changes in body composition and function, which can affect the pharmacodynamics and pharmacokinetics of many drugs. This paper aims to discuss the application of muscle relaxants and their reversing agents in patients with morbid obesity.
View Article and Find Full Text PDFAdverse events related to neuromuscular blocking agents: a disproportionality analysis of the FDA adverse event reporting system.
Front Pharmacol
July 2024
Department of Pharmacy, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Article Synopsis
- Neuromuscular blocking agents (NMBAs) are used during surgeries to assist with intubation and improve operating conditions, but their safety was the focus of this study.
- The research analyzed data from the FDA's adverse event reporting system, looking at four specific NMBAs (atracurium, cisatracurium, rocuronium, and vecuronium) over almost two decades.
- Findings revealed a total of 11,518 adverse events associated with these drugs, with significant signals related to various serious health issues, including cardiac and respiratory disorders, and identified new adverse events like ventricular fibrillation and Kounis syndrome.
The Influence of Acid-Base Balance on Anesthetic Muscle Relaxants: A Comprehensive Review on Clinical Applications and Mechanisms.
Med Sci Monit
July 2024
Department Anaesthesiology and Intensive Care, Faculty of Medicine, Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland.
Muscle relaxants have broad application in anesthesiology. They can be used for safe intubation, preparing the patient for surgery, or improving mechanical ventilation. Muscle relaxants can be classified based on their mechanism of action into depolarizing and non-depolarizing muscle relaxants and centrally acting muscle relaxants.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!