AI Article Synopsis
- Sucralfate is an aluminum-based compound used orally for treating gastrointestinal issues like reflux and ulcers, but recent studies show its effectiveness in healing various skin and mucosal wounds when applied topically.
- The process of epithelial wound healing involves several phases, including blood clotting, inflammation, cell growth, and tissue remodeling to repair the damaged area.
- The report examines clinical evidence supporting topical sucralfate for epithelial wounds, explores its molecular action in healing, and discusses relevant patents associated with its use.
Article Abstract
Sucralfate is a basic aluminium salt of sucrose octasulphate which was orally employed for prevention and treatment of several gastrointestinal diseases including gastroesophageal reflux, gastric and duodenal ulcer. Recent studies have employed sucralfate as a topical drug for the healing of several types of epithelial wounds such as ulcers, inflammatory dermatitis, mucositis and burn wounds. Epithelial wound healing is a well orchestrated process involving hemostasis, inflammatory reaction, cell proliferation and tissue remodelling which leads to granulation tissue development and filling of the wound space. This report will review clinical evidences on the use of topical sucralfate for the management of epithelial lesions and deal with the current knowledge on the molecular mechanisms of action of this compound towards the epithelial wound healing process and will also discuss relevant patents.
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| http://dx.doi.org/10.2174/187221310789895649 | DOI Listing |
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