Background: Although medicinal carbon (MC) is useful to treat intoxications caused by orally taken toxic chemicals or toxins, high dose of MC is a burden on patients and sticks to oral mucosa or throat. A tablet dosage form of MC is useful to solve such problems. Fast-disintegration, adequate hardness, and quick and high-adsorption potential are required for MC tablets.
Method: A modified wet compression method using carboxymethylcellulose sodium (CMC-Na) solution as binder solution was newly developed. Croscarmellose sodium (CC-Na) was used as a disintegration agent. MC granules, binder solution, and MC granules were placed in the cylinder in that order, and the resultant mass was compressed. The obtained tablets were examined for hardness, disintegration rate, and acetaminophen adsorption profiles.
Results: The tablets, produced with MC granules containing CMC-Na and CC-Na at 10% each and using 280 microL of 2.5% (w/w) CMC-Na binder solution in compression, showed adequate hardness (more than 4 kg), short disintegration time (less than 6 min), and almost the same acetaminophen adsorption profile as intact MC powder.
Conclusion: The modified wet compression with CMC-Na and CC-Na is suggested to be useful to obtain MC tablets with good quality.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/03639040902902419 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Experimental study on the mechanical properties of modified phosphogypsum at different loading rates.
Sci Rep
December 2024
School of Civil Engineering and Architecture, Guizhou Minzu University, Guiyang, 550025, China.
Phosphogypsum is the main industrial solid waste from wet process phosphoric acid production, which has significant potential for environmental sustainability and engineering applications when modified. In order to explore the mechanical properties of modified phosphogypsum (MG) in different loading environments, uniaxial compression tests were conducted at four loading rates: 0.03, 0.
View Article and Find Full Text PDFToward mechanistic understanding of wettability alteration in carbonate rocks in the presence of nanoparticles, gelatin biopolymer, and core-shell nanocomposite of FeO@gelatin.
Sci Rep
December 2024
Department of Petroleum Engineering, Shahid Bahonar University of Kerman, Kerman, Iran.
Because a significant portion of oil remains in carbonate reservoirs, efficient techniques are essential to increase oil recovery from carbonate reservoirs. Wettability alteration is crucial for enhanced oil recovery (EOR) from oil-wet reservoirs. This study investigates the impact of different substances on the wettability of dolomite and calcite rocks.
View Article and Find Full Text PDFPreparation of quaternary ammonium lignosulfonate modified UV resistant polyurethane and its application in leather dyeing.
Int J Biol Macromol
December 2024
Fujian Key Laboratory of Leather Green Design and Manufacture, Jinjiang 362271, Fujian, China.
Applying cationic waterborne polyurethane (CWPU) in the leather color-fixing process can improve the dyeing rate and enhance color fastness. However, under prolonged exposure to sunlight, CWPU will age and degrade and the leather will fade in color, become stiff and crack easily. In this study, an Ultraviolet absorber was introduced into cationic waterborne polyurethane (UVCWPU) and quaternary ammonium Lignosulfonate (QLS) was prepared by quaternization.
View Article and Find Full Text PDFMagnetically Induced Anisotropic Microstructures on Polyethylene Glycol Hydrogel Facilitate BMSC Alignment and Osteogenic Differentiation.
Gels
December 2024
Research Institute of Smart Medicine and Biological Engineering, Health Science Center, Ningbo University, Ningbo 315211, China.
Many tissues exhibit structural anisotropy, which imparts orientation-specific properties and functions. However, recapitulating the cellular patterns found in anisotropic tissues presents a remarkable challenge, particularly when using soft and wet hydrogels. Herein, we develop self-assembled anisotropic magnetic FeO micropatterns on polyethylene glycol hydrogels utilizing dipole-dipole interactions.
View Article and Find Full Text PDFThe Combination of Aligned PDA-Fe@PLCL Conduit with Aligned GelMA Hydrogel Promotes Peripheral Nerve Regeneration.
Adv Healthc Mater
December 2024
Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
Biomaterial-assisted therapeutic strategies enable precise modulation to direct endogenous cellular responses and harness regenerative capabilities for nerve repair. However, achieving effective cellular engagement during nerve remodeling remains challenging. Herein, a novel composite nerve guidance conduit (NGC), the GelMA/PLys@PDA-Fe@PLCL conduit is developed by combining aligned poly(l-lactide-co-caprolactone) (PLCL) nanofibers modified with polydopamine (PDA), ferrous iron (Fe⁺), and polylysine (PLys) with aligned methacrylate-anhydride gelatin (GelMA) hydrogel nanofibers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!