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Deep learning algorithm enables automated Cobb angle measurements with high accuracy.
Skeletal Radiol
December 2024
Department of Radiology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA.
Objective: To determine the accuracy of automatic Cobb angle measurements by deep learning (DL) on full spine radiographs.
Materials And Methods: Full spine radiographs of patients aged > 2 years were screened using the radiology reports to identify radiographs for performing Cobb angle measurements. Two senior musculoskeletal radiologists and one senior orthopedic surgeon independently annotated Cobb angles exceeding 7° indicating the angle location as either proximal thoracic (apices between T3 and T5), main thoracic (apices between T6 and T11), or thoraco-lumbar (apices between T12 and L4).
Methionine-driven YTHDF1 expression facilitates bladder cancer progression by attenuating RIG-I-modulated immune responses and enhancing the eIF5B-PD-L1 axis.
Cell Death Differ
December 2024
Department of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
The impact of amino acids on tumor immunotherapy is gradually being uncovered. In this study, we screened various essential and non-essential amino acids and found that methionine enhances mRNA methylation and reduced the activation of Type I interferon pathway in bladder cancer. Through RNA sequencing, point mutations, MB49 mouse tumor models, and single-cell RNA sequencing, we demonstrated that high methionine levels elevate the expression of mA reader YTHDF1, promoting the degradation of RIG-I, thereby inhibiting the RIG-I/MAVS-mediated IFN-I pathway and reducing the efficacy of tumor immunotherapy.
View Article and Find Full Text PDFRNA methylation and breast cancer: insights into m6A, m7G and m5C.
Mol Biol Rep
November 2024
Department of breast surgery, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
Article Synopsis
- - Breast cancer is the most common cancer diagnosed in women globally, characterized by its diverse molecular makeup and complex types, which pose challenges in treatment due to tumor heterogeneity and resistance.
- - Recent research has identified nearly 200 RNA modifications, with methylation playing a crucial role in cancer development, progression, and treatment resistance, particularly the N6-methyladenosine (m6A) modification, which involves key "writers," "readers," and "erasers."
- - The review discusses various RNA methylation types (m6A, m7G, m5C, m1A, and m3C), their effects on tumor behavior, and highlights their potential as therapeutic targets, suggesting they may enhance
[Corrigendum] Anti‑carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane‑induced colonic aberrant crypt foci formation in rats.
Int J Oncol
January 2025
Center for Chemoprevention and Cancer Drug Development, Department of Medicine, Hem-Onc Section, PC Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Following the publication of the above article, an interested reader drew to the authors' attention that certain of the in vitro image panels shown in Fig. 3B (featuring the effects of adding five different concentrations of omeprazole on acridine orange/ethidium bromide‑stained HCA‑7 cells) and Fig. 4 (showing western blotting experiments) on p.
View Article and Find Full Text PDF[Corrigendum] Spicatoside A in red displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling.
Int J Mol Med
February 2025
Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang 627-706, Republic of Korea.
Following the publication of the above article, an interested reader drew to the Editor's attention that various of the histological structural images shown in Fig. 5 on p. 190 were strikingly similar to data that were featured in Fig.
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