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Joint image reconstruction and segmentation of real-time cardiac MRI in free-breathing using a model based on disentangled representation learning.
J Cardiovasc Magn Reson
January 2025
Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany.
Purpose: To investigate image quality and agreement of derived cardiac function parameters in a novel joint image reconstruction and segmentation approach based on disentangled representation learning, enabling real-time cardiac cine imaging during free-breathing.
Methods: A multi-tasking neural network architecture, incorporating disentangled representation learning, was trained using simulated examinations based on data from a public repository along with MR scans specifically acquired for model development. An exploratory feasibility study evaluated the method on undersampled real-time acquisitions using an in-house developed spiral bSSFP pulse sequence in eight healthy participants and five patients with intermittent atrial fibrillation.
Dynamic soil columns simulate Arctic redox biogeochemistry and carbon release during changes in water saturation.
Sci Rep
January 2025
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.
Thawing Arctic permafrost can induce hydrologic change and alter redox conditions, shifting the balance of soil organic matter (SOM) decomposition. There remains uncertainty about how soil saturation and redox transitions impact dissolved and gas phase carbon fluxes, and efforts to link hydrobiogeochemical processes to ecosystem-scale models are limited. This study evaluates SOM decomposition of Arctic tundra soils using column experiments, water chemistry measurements, microbial community analysis, and a PFLOTRAN reactive transport model.
View Article and Find Full Text PDFObjective: This study explores the effectiveness of conversational prompts on enhancing driver monitoring behavior and takeover performance in partially automated driving under two non-driving-related task (NDRT) scenarios with varying workloads.
Background: Driver disengagement in partially automated driving is a serious safety concern. Intermittent conversational prompts that require responses may be a solution.
Variable temocillin protein binding and pharmacokinetics in different clinical conditions: Implications for target attainment.
Br J Clin Pharmacol
January 2025
Department of Medical Microbiology, Haaglanden Medisch Centrum, The Hague, The Netherlands.
Aims: The beta-lactam antibiotic temocillin is increasingly used to treat extended-spectrum beta-lactamase (ESBL-producing) strains; however, its protein binding is complex. This study aims to predict unbound temocillin concentrations in various participant groups to determine its impact on the probability of target attainment (PTA) and to improve dosing recommendations.
Methods: The plasma pharmacokinetics were analysed using non-linear mixed-effects modelling.
Dosing and route of administration of clindamycin given in combination with rifampicin.
Clin Microbiol Infect
January 2025
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, F-75018 Paris, France; Unité Fonctionelle de Pharmacologie, GHU Paris Seine Saint-Denis, Assistance Publique-Hôpitaux de Paris (APHP), Université Sorbonne Paris Nord, Bondy, France.
Article Synopsis
- The study developed a pharmacokinetic (PK) interaction model for clindamycin when used with rifampicin to assess effective dosing strategies.
- It involved analyzing 518 plasma samples from 124 patients to determine how different administration routes and doses of clindamycin could achieve necessary drug concentrations.
- The findings revealed that rifampicin significantly increased the clearance of clindamycin, rendering oral administration ineffective and suggesting that a higher IV dose of clindamycin is required to treat infections effectively.
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