AI Article Synopsis
- A study on hyperlipidemic male rats examined how exercise training affects heart health, specifically looking at blood flow, lipid levels, inflammatory markers, and nerve receptor expression in the heart.
- After 8 weeks of a high-fat diet combined with exercise, the rats showed improved blood lipid profiles and reduced inflammation, leading to better heart function.
- The results suggest that exercise training boosts the expression of certain heart-related nerves and receptors, which contributes to the exercise benefits for cardiac health in rats with hyperlipidemia.
Article Abstract
The role of exercise training on hemodynamic parameters, blood lipid profiles, inflammatory cytokines, cholinesterase-positive nerves and muscarinic cholinergic (M(2)) receptors expression in the heart was investigated in Sprague-Dawley male rats with hyperlipidemia (HL). The rats were subjected to a high-fat diet and exercise training for 8 weeks, and then the hemodynamic parameters, the profiles of blood lipid and inflammatory cytokines, and the expression of cholinesterase-positive nerves and M(2) receptors were measured. HL rats displayed cardiac dysfunction, dysregulation of inflammatory cytokines, and decreased cholinesterase-positive nerves and M(2) receptors expression. The combination of hyperlipidemia with exercise training (AT) restored the profiles of blood lipids and the levels of inflammatory cytokines. In addition, AT and HL + AT improved cardiac function with increasing cholinesterase-positive nerves and M(2) receptors expression. Overall, these data show that the increased expression of cholinesterase-positive nerves and M(2) receptors in the heart is partially responsible for the benefits of exercise training on cardiac function in hyperlipidemia rats.
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| http://dx.doi.org/10.1007/s00421-009-1232-1 | DOI Listing |
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Article Synopsis
- A study on hyperlipidemic male rats examined how exercise training affects heart health, specifically looking at blood flow, lipid levels, inflammatory markers, and nerve receptor expression in the heart.
- After 8 weeks of a high-fat diet combined with exercise, the rats showed improved blood lipid profiles and reduced inflammation, leading to better heart function.
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