3,5-Isoxazoles from alpha-bromo-pentafluorophenyl vinylsulfonates: synthesis of sulfonates and sulfonamides.

Org Biomol Chem

Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, UK WC1H 0AJ.

Published: November 2009

The regioselective 1,3-dipolar cycloaddition of alpha-bromo-pentafluorophenyl vinylsulfonate with nitrile oxides has been used to rapidly access a range of 3,5-isoxazoles which could be converted directly to their corresponding sulfonamides.

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Source
http://dx.doi.org/10.1039/b911098dDOI Listing

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