We have constructed a small-bore insertable gradient coil with two linear gradient imaging regions and interfaced it with an MRI scanner. We have also constructed an RF system capable of transmitting or receiving in both regions simultaneously.Designs for conductor placement for two-region X-, Y- and Z-gradient coils were optimized by simulated annealing. Wire patterns for each axis were chosen that gave low inductance, reasonable homogeneity over a large imaging volume and high efficiency (gradient field per-unit-current).Imaging was performed on a Siemens 3T TIM Trio scanner equipped with three additional gradient amplifier channels and a second RF/gradient array controller. Phantoms were placed in the two imaging regions as well as the central non-imaging region to test gradient homogeneity and crosstalk between regions. Images acquired simultaneously in the two regions showed very little signal crosstalk between imaging regions and even less signal from the central, non-imaging region.When combined with an overlapping single-region gradient insert, extended field-of-view (FOV) imaging will be possible without moving the table or the subject and without increasing nerve stimulation. Construction and testing of a two-region gradient coil insert is a necessary intermediate step as a proof of concept for an extended field of view, contiguous, three-region human-sized gradient system.
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http://dx.doi.org/10.1002/cmr.b.20138 | DOI Listing |
Tomography
January 2025
NextGen Precision Health, Department of Radiology, University of Missouri Columbia, 1030 Hitt Street, Columbia, MO 65201, USA.
: The increased SNR available at 7T combined with fast readout trajectories enables accelerated spectroscopic imaging acquisitions for clinical applications. In this report, we evaluate the performance of a Hadamard slice encoding strategy with a 2D rosette trajectory for multi-slice fast spectroscopic imaging at 7T. : Moderate-TE (~40 ms) spin echo and J-refocused polarization transfer sequences were acquired with simultaneous Hadamard multi-slice excitations and rosette in-plane encoding.
View Article and Find Full Text PDFJ Magn Reson Imaging
January 2025
Neuromuscular Research Center, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background: Quantitative Susceptibility Mapping (QSM) provides a non-invasive post-processing method to investigate alterations in magnetic susceptibility (χ), reflecting iron content within brain regions implicated in neurodegenerative diseases (NDDs).
Purpose: To investigate alterations in thalamic χ in patients with NDDs using QSM.
Study Type: Systematic review and meta-analysis.
Phys Med Biol
January 2025
Department of Physics, Aristotle University of Thessaloniki, University Campus, Thessaloniki, 54124, GREECE.
Magnetic nanoparticle hyperthermia (MNH) emerges as a promising therapeutic strategy for cancer treatment, leveraging alternating magnetic fields (AMFs) to induce localized heating through magnetic nanoparticles (MNPs). However, the interaction of AMFs with biological tissues leads to non-specific heating caused by eddy currents, triggering thermoregulatory responses and complex thermal gradients throughout the body of the patient. While previous studies have implemented the Atkinson-Brezovich limit to mitigate potential harm, recent research underscores discrepancies between this threshold and clinical outcomes, necessitating a re-evaluation of this safety limit.
View Article and Find Full Text PDFNeuroimage
January 2025
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, USA. Electronic address:
Introduction: Ultra-high-field magnetic resonance (MR) systems (7 T and 9.4 T) offer the ability to probe human brain metabolism with enhanced precision. Here, we present the preliminary findings from 3D MR spectroscopic imaging (MRSI) of the human brain conducted with the world's first 10.
View Article and Find Full Text PDFFront Neurol
December 2024
Department of Neurology, Headache Outpatient Clinic, Medical University of Innsbruck, Innsbruck, Austria.
Background: There is evidence that iron metabolism may play a role in the underlying pathophysiological mechanism of migraine. Studies using (=1/ ) relaxometry, a common MRI-based iron mapping technique, have reported increased values in various brain structures of migraineurs, indicating iron accumulation compared to healthy controls.
Purpose: To investigate whether there are short-term changes in during a migraine attack.
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