Objective: To analyze the relationship between plasma level of cortistatin(CST) and coronary heart disease(CHD) and the factors that influence the level of CST.
Methods: Plasma levels of CST were measured using ELISA method. The clinical data and the levels of CST of 40 healthy subjects and 39 CHD patients before and 1 d after percutaneous coronary intervention (PCI) were compared. And the factors that influenced the CST level were analyzed.
Results: The CST levels of CHD group before or 1 d after PCI were significantly higher than those of the control group (1.97+/-1.12 and 2.01+/-0.77 vs 1.21+/-0.27, P<0.01);The procedure of PCI didn't influence the CST levels(1.97+/-1.12 vs 2.01+/-0.77, P>0.05);There was no correlation between CST levels and fasting blood glucose(FBG), high sensitivity C-reactive protein (hsCRP), left ventricular ejection fraction(LVEF), severity of lesions of coronary arteries or history of hypertension; The levels of triglyceride(TG) and total cholesterol(TCHOL) negatively correlated with CST levels(beta=-2.594, P<0.05;and beta=-0.650, P<0.01), but history of diabetes mellitus(DM) or myocardial infarction(MI) positively correlated with CST levels(beta=4.149 and 6.430, P<0.05).The CST level of subgroup of CHD with DM or MI was higher than that of CHD without DM or MI, but the difference was not significant(2.07+/-10.7 vs 1.85+/-1.20; 2.20+/-1.53 vs 1.79+/-0.66, P<0.05).
Conclusion: Patients with CHD have higher plasma levels of CST. CST may play an important role in the procedure of CHD.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Examining Heart Failure Informal Care Partners Using Person and System Levels and Domains: A Meta-Synthesis.
West J Nurs Res
January 2025
Florida State University College of Nursing, Tallahassee, FL, USA.
Background: Within the last decade, system and policy-level changes have driven substantial shifts in heart failure (HF) care from hospital to home, requiring greater support from informal care partners. What has not been examined is the state of the care partner science by person and system-level domains using qualitative studies to understand impact across multiple person and system levels.
Objectives: (1) Identify by person and system levels and domain what is known about informal care partners and (2) Identify gaps in the caregiving science and suggest ways to move forward.
Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells.
Invest Ophthalmol Vis Sci
January 2025
Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou, China.
Purpose: To investigate the therapeutic efficacy of BEZ235, a dual PI3K/mTOR inhibitor, in suppressing pathological neovascularization in an oxygen-induced retinopathy (OIR) mouse model and explore the role of cyclin D1 in endothelial cell cycle regulation.
Methods: Single-cell RNA sequencing was performed to analyze gene expression and cell-cycle alterations in retinal endothelial cells under normoxic and OIR conditions. The effects of BEZ235 on human umbilical vein endothelial cells (HUVECs) and human retinal microvascular endothelial cells (HRMECs) were evaluated by assessing cell viability, cell-cycle progression, proliferation, migration, and tube formation.
Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity.
JAMA Netw Open
January 2025
Healthcare Transformation Institute, Department of Medical Ethics and Health Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Importance: Adherence to glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is important for their effectiveness. Discontinuation and reinitiation patterns are not well understood.
Objective: To describe rates of and factors associated with discontinuation and subsequent reinitiation of GLP-1 RAs among adults with overweight or obesity.
Which Training Intensity Distribution Intervention will Produce the Greatest Improvements in Maximal Oxygen Uptake and Time-Trial Performance in Endurance Athletes? A Systematic Review and Network Meta-analysis of Individual Participant Data.
Sports Med
January 2025
Department of Sport Science and Physical Education, Faculty of Health and Sport Sciences, University of Agder, Kristiansand, Norway.
Background: Endurance athletes tend to accumulate large training volumes, the majority of which are performed at a low intensity and a smaller portion at moderate and high intensity. However, different training intensity distributions (TID) are employed to maximize physiological and performance adaptations.
Objective: The objective of this study was to conduct a systematic review and network meta-analysis of individual participant data to compare the effect of different TID models on maximal oxygen uptake (VO) and time-trial (TT) performance in endurance-trained athletes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!