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Kidney Targeting Smart Antibiotic Discovery: Multimechanism Pleuromutilins for Pyelonephritis Therapy.
J Med Chem
January 2025
Xi'an Key Laboratory for Antiviral and Antimicrobial-Resistant Bacteria Therapeutics Research, Xi'an 710021, China.
Multidrug-resistant (MDR) bacteria pose a global health threat, underscoring the need for new antibiotics. Lefamulin, the first novel-mechanism antibiotic approved by the FDA in decades, showcases pleuromutilins' promise due to low mutation frequency. However, their clinical use is limited by poor pharmacokinetics and organ toxicity.
View Article and Find Full Text PDFStable Air Plastron Prolongs Biofluid Repellency of Submerged Superhydrophobic Surfaces.
Langmuir
January 2025
School of Chemical Engineering, Department of Chemistry and Materials Science, Aalto University, Tietotie 3 Espoo 02150, Finland.
Superhydrophobic surfaces find applications in numerous biomedical scenarios, requiring the repellence of biofluids and biomolecules. Plastron, the trapped air between a superhydrophobic surface and a wetting liquid, plays a pivotal role in biofluid repellency. A key challenge, however, is the often short-lived plastron stability in biofluids and the lack of knowledge surrounding it.
View Article and Find Full Text PDFBalloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: short- and long-term results from a cohort in Brazil.
J Bras Pneumol
January 2025
. Instituto D'Or de Pesquisa e Ensino - IDOR - Hospital Cárdio-Pulmonar, Rede D'Or, Salvador (BA) Brasil.
Objective: A significant number of patients with chronic thromboembolic pulmonary hypertension (CTEPH) are not eligible for pulmonary endarterectomy and may be treated with balloon pulmonary angioplasty (BPA). Although BPA programs have recently been developed in Brazil, no results have yet been published. The objective of this study was to assess the clinical and hemodynamic progression of the first patients treated with BPA at our center.
View Article and Find Full Text PDFAnalyzing robust dividend payout policy with dynamic panel regression: Application of speed of adjustment to half-life.
PLoS One
January 2025
Faculty of Business Administration, Thongsook College, Bangkok, Thailand.
This study aims to observe the effects of financial metrics, free float shareholders, GDP growth and firm age on dividend payout policy in both the short- and long-term scenarios. The study introduces the dynamic panel regression models, i.e.
View Article and Find Full Text PDFEvaluating the Effectiveness of a Mobile Health Intervention on Enhancing HIV Knowledge in Sexual and Gender Minority Men.
J Acquir Immune Defic Syndr
November 2024
Columbia University School of Nursing, New York, NY, United States.
Background: In the United States, young men who have sex with men (YMSM) and young transgender women (YTGW) are disproportionately affected by HIV infection. Adequate HIV knowledge is critical for protecting adolescents and young adults at risk for HIV. This study aimed to evaluate the effectiveness of the mLab App intervention in enhancing HIV knowledge among YMSM and YTGW.
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