Wegener's granulomatosis (WG) is a primary systemic vasculitis characterized by the development of granulomatous inflammation and necrotizing vasculitis of small- and middle-sized vessels. The clinical symptoms of the involvement of lacrimal organs in WG are of no specificity. Lacrimal tract lesion is encountered in prolonged Wegener's granulomatosis. Whether surgical intervention can and should be made in these patients remains to be debated. Successful surgical treatment for chronic dacryocystitis with recurrent lacrimal sac phlegmon in a female patient with WG has been used as an example to show that endoscopic endonasal dacryocystorhinostomy is the most sparing surgical treatment of dacryocystitis and therefore it is preferable in WG patients and effective at remission during systemic therapy with additional doses of corticosteroids in the pre- and postoperative periods. Lacrimal gland involvement (more commonly diffuse infiltration) is observed at the early stages of the disease and may be the first manifestation of WG so the latter should be excluded when long-term therapy for chronic dacryoadenitis fails.
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Zhen Ci Yan Jiu
December 2024
Department of Acupuncture and Moxibustion, China Japan Friendship Hospital, Beijing 100029.
Objectives: To observe the clinical effect on perimenopausal dry eye disease treated with He's fire needle therapy combined with walnut-shell moxibustion.
Methods: A total of 60 patients with perimenopausal dry eye disease were randomized into an observation group (30 cases) and a control group (30 cases). In the observation group, the pricking technique with fire needle was operated at bilateral Naokong (GB19), Feishu (BL13), Xinshu (BL15), Ganshu (BL18), Pishu (BL20), Shenshu (BL23), 3 times a week, for 4 weeks, and the walnut-shell moxibustion was combined, 30 minutes each time, 3 times a week, for 4 weeks.
Immunol Med
November 2024
Kanazawa University, Ishikawa, Japan.
We started a registry for cases of immunoglobulin (Ig)G4-related disease (IgG4-RD) in December 2019 to clarify the clinical profile of IgG4-RD. In this study, clinical information from 854 cases registered by February 16, 2024 was analyzed from multiple perspectives. Diagnosis of IgG4-RD was made in 808 cases, comprising 638 definite, 38 probable, and 132 possible.
View Article and Find Full Text PDFAdv Colloid Interface Sci
January 2025
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310000, China. Electronic address:
To date, genetically modified organoids are emerging as a promising 3D modeling tool aimed at solving genetically relevant clinical and biomedical problems for regenerative medicine and tissue engineering. As an optimal vehicle for gene delivery, genetically modified organoids can enhance or reduce the expression of target genes through virus and non-virus-based gene transfection methods to achieve tissue regeneration. Animal experiments and preclinical studies have demonstrated the beneficial role of genetically modified organoids in various aspects of organ regeneration, including thymus, lacrimal glands, brain, lung, kidney, photoreceptors, etc.
View Article and Find Full Text PDFRambam Maimonides Med J
October 2024
The B. Shine Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel.
IgG4-related disease (IgG4-RD) is a rare illness with inflammatory and fibrotic changes in affected organs such as pancreas, thyroid, salivary or lacrimal glands, and retroperitoneal space; rarely other organs may be involved. IgG4-related breast disease (IgG4-BD) is very rare and generally presents as a lump or mastitis. IgG4-BD as a presenting feature of IgG4-RD is extremely rare.
View Article and Find Full Text PDFCureus
October 2024
Nephrology, Okayama University Hospital, Okayama City, JPN.
Immunoglobulin G4 (IgG4)-related disease is characterized by infiltration with IgG4-producing plasma cells in different organs and the elevation of serum IgG4. We present a patient with polycystic kidney disease in long-term follow-up who developed bilateral lacrimal gland enlargement and presumed IgG4-related choroidopathy at different time points. A 45-year-old woman developed bilateral upper eyelid swelling.
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