Cesare Bertagnini was a student of Raffaele Piria. He took orally various acids (nitrobenzoic, camphoric and salicylic) and dosed these compounds and metabolites in his own urines. He acted as a precursor of pharmacokinetics.
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[A short history of anti-rheumatic therapy. II. Aspirin].
Reumatismo
October 2010
Università di Pisa, Italia.
The discovery of aspirin, an antipyretic, anti-inflammatory and analgesic drug, undoubtedly represents a milestone in the history of medical therapy. Since ancient times the derivatives of willow (Salix alba) were used to treat a variety of fevers and pain syndromes, although the first report dates back to 1763 when the English Reverend Edward Stone described the effect of an extract of the bark willow in treating malaria. In the XIX century many apothecaries and chemists, including the Italian Raffaele Piria and Cesare Bertagnini, developed the biological processes of extraction and chemical synthesis of salicylates, and then analyzed their therapeutic properties and pharmacokinetic and pharmacodynamic characteristics.
View Article and Find Full Text PDF[Some notes on Cesare Bertagnini, pioneer of pharmacokinetics].
Rev Hist Pharm (Paris)
April 2009
Clinique de rhumatologie, Université de Pise, Italie.
Cesare Bertagnini was a student of Raffaele Piria. He took orally various acids (nitrobenzoic, camphoric and salicylic) and dosed these compounds and metabolites in his own urines. He acted as a precursor of pharmacokinetics.
View Article and Find Full Text PDFThe discovery of salicylate ototoxicity.
Audiol Neurootol
January 2008
Section of Otolaryngology, Department of Medical and Surgical Specialties, University of Padova, Padova, Italy.
Although the name of the discoverer of salicylate ototoxicity is still debated, most authors have quoted Muller and his 1877 report. To the best of our knowledge, the true discoverer of the transient ototoxicity of salicylate was the Italian chemist Cesare Bertagnini who reported this evidence in 1855 in the journal Il Nuovo Cimento.
View Article and Find Full Text PDF[The Italian contributions to the history of salicylates].
Reumatismo
July 2006
Unità di Emaferesi, Servizio Immunotrasfusionale, Azienda Ospedaliera di Padova.
It is well-known that the modern history of salicylates began in 1899 when the compound acetylsalicylic acid was registered and introduced commercially as "aspirin" by the Bayer Company of Germany. As a matter of fact, however, remedies made from willow bark had been used to treat fever and rheumatic complaints at least since 1763, when Edward Stone described their efficacy against malarian fever. A number of Italian scientists made significant contributions during the long period of research leading up to the synthesis of acetylsalicylic acid and its widespread use in rheumatic diseases.
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