The purpose of this study was to investigate the operative results and the clinical outcomes of Portuguese octogenarians who underwent cardiac surgery. Records of 339 consecutive octogenarians who had had cardiac operations between 2003 and 2005 were reviewed. The effect of cardiac and operative risk factors on mortality was evaluated. Selected variables included risk factors, cardiac status, preoperative hemodynamics and surgical procedures were collected on all patients. The mean age was 82.4+/-2.4 years-old (range 80-94) and 51.9% were male. Octogenarians had often diabetes (23.6%), renal failure (5.9%), cerebrovascular disease (8.3%), peripheral vascular disease (16.5%) and chronic lung disease (10.0%). The surgical priority was elective for 206 patients, urgent for 120 patients and it was emergent for 8 patients. Coronary artery bypass grafting was performed in 46.9%of patients, valve surgery was performed in 31.6% and combination of these in 19.5% of patients. Overall hospital mortality was 10.0%. Operative mortality for coronary artery bypass and valve surgery were 9.4% and 8.0%, respectively. Combined surgery (16.7%), diabetes (15.7% vs 9.3%, p<0.05), and urgent/emergent (14.3% vs 7.3%, p<0,05) increased significantly operative mortality. In conclusion, cardiac surgery can be performed within acceptable limits of risk and an acceptable mortality. Several factors might help both in case selection and in perioperative decisions.
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Transl Oncol
January 2025
Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Naval Medical University (Second Military Medical University), 168 Changhai Road, Shanghai 200433, China. Electronic address:
Purpose The present study aimed to clarify the distribution pattern of carcinoma associated fibroblasts (CAFs) across pancreatic ductal adenocarcinoma (PDAC) and its prognostic prediction value. Methods Data of two cohorts were retrospectively collected from consecutive patients who underwent primary pancreatic resection from January 2015 to December 2017. We used tumor specimens to screen out the most suitable markers for the spatial distribution analysis for CAFs subpopulations.
View Article and Find Full Text PDFHepatology
January 2025
Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Preventive interventions are expected to substantially improve the prognosis of patients with primary liver cancer, predominantly hepatocellular carcinoma (HCC) and cholangiocarcinoma. HCC prevention is challenging in the face of the evolving etiological landscape, particularly the sharp increase in obesity-associated metabolic disorders, including metabolic dysfunction-associated steatotic liver disease (MASLD). Next-generation anti-HCV and HBV drugs have substantially reduced, but not eliminated, the risk of HCC and have given way to new challenges in identifying at-risk patients.
View Article and Find Full Text PDFBlood
January 2025
Children's Hospital of Philadelphia & University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States.
Robust genetic characterization of paediatric AML has demonstrated that fusion oncogenes are highly prevalent drivers of AML leukemogenesis in young children. Identification of fusion oncogenes associated with adverse outcomes has facilitated risk stratification of patients, although successful development of precision medicine approaches for most fusion-driven AML subtypes have been historically challenging. This knowledge gap has been in part due to difficulties in targeting structural alterations involving transcription factors and in identification of a therapeutic window for selective inhibition of the oncofusion without deleterious effects upon essential wild-type proteins.
View Article and Find Full Text PDFIn unrelated allogeneic hematopoietic cell transplantation (allo-HCT), older and/or HLA-mismatched donors are known risk factors for survival outcomes. In healthy individuals, cytomegalovirus (CMV) seropositivity is associated with impaired adaptive immune systems. We assessed whether the adverse effects of donor risk factors are influenced by the donor CMV serostatus.
View Article and Find Full Text PDFJ Trauma Nurs
January 2025
Author Affiliations: Trauma Prevention Program, UC Davis Medical Center, University of California Davis, Sacramento, California (Dr Adams); Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California (Dr Tancredi); Betty Irene Moore School of Nursing, University of California Davis, Sacramento, California (Drs Bell and Catz); and Division of General Internal Medicine, School of Medicine and Center for Healthcare Policy and Research, University of California Davis, Sacramento, California (Dr Romano).
Background: Acute care hospitalization has been associated with older adult home falls after discharge, but less is known about the effects of hospital- and patient-related factors on home fall risk.
Objectives: This study compares the effects of hospital length of stay, medical condition, history of falls, and home health care on period rates of home falls after discharge from acute care hospitalization.
Methods: This was a retrospective cohort study comparing period rates of home injury falls among older adults (age ≥ 65) occurring after discharge from an acute care hospitalization.
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