In May 2008, a report of two workers from the same construction equipment manufacturing plant who were admitted to hospital with Legionnaires disease confirmed by urine antigen prompted an outbreak investigation. Both cases were middle aged men, smokers, and with no travel, leisure or other common community exposure to Legionella sources. There were no wet cooling towers at the plant or in the surrounding area. No increase in respiratory disease or worker absenteeism occurred at the plant during the preceding month. Wider case ascertainment including alerts to hospitals and medical practitioners yielded no further cases. The environmental investigation (and sampling of water systems for Legionella) identified a Legionella pneumophila serogroup1 (Mab 2b) count of >3.0x10(4)cfu/l in water samples from an aqueous metal pre-treatment tunnel, which generates profuse water aerosol. Drainage, cleaning and biocide treatment using thiazalone eliminated Legionella from the system.
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PLoS Comput Biol
December 2024
Department of Mathematics, University of Manchester, Manchester, United Kingdom.
Understanding the temporal relationship between key events in an individual's infection history is crucial for disease control. Delay data between events, such as infection and symptom onset times, is doubly censored because the exact time at which these key events occur is generally unknown. Current mathematical models for delay distributions are derived from heuristic justifications.
View Article and Find Full Text PDFCureus
November 2024
Nephrology, Kanazawa Medical University, Kahoku, JPN.
Legionnaires' disease is a bacterial infection caused by , such as . It mainly causes severe pneumonia, with symptoms such as fever, cough, and shortness of breath. In rare cases, it can cause acute kidney disease and also occasionally become severe enough to require replacement therapy.
View Article and Find Full Text PDFInn Med (Heidelb)
December 2024
Klinik für Innere Medizin, Rheumatologie, Pneumologie, Nephrologie und Diabetologie, medius Klinik Kirchheim, Kirchheim unter Teck, Deutschland.
A 48-year-old male patient was admitted to hospital with Legionella pneumonia. He developed a splenic rupture 1 day after admission, which was surgically treated. Retrospectively, the splenomegaly could already be seen by sonography on admission.
View Article and Find Full Text PDFEvolving technology and the development of new devices that can aerosolize water present a risk for new sources of Legionella bacteria growth and spread within industrial settings. We investigated a cluster of legionellosis among employees of a manufacturing facility in South Carolina, USA, and found 2 unique equipment sources of Legionella bacteria. The cluster of cases took place during August-November 2022; a total of 34 cases of legionellosis, including 15 hospitalizations and 2 deaths, were reported.
View Article and Find Full Text PDFJ Occup Environ Med
December 2024
Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, NY, USA.
Objectives: To assess combat and combat-related posttraumatic stress disorder (PTSD) as risk factors for heart disease and non-cardiac chronic disease comorbidity in deployed Vietnam veterans 50 years post-War.
Methods: A random sample of 735 Vietnam-deployed American Legionnaires was surveyed in 1984, 1998, and 2000 for combat exposure, probable PTSD, and history of diagnosed chronic illnesses.
Results: Twenty-eight percent reported a diagnosed heart condition; combat exposure in Vietnam was a significant predictor (OR = 1.
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