The authors applied the meaning extraction method (MEM) to 4,241 e-mails written by 297 participants of an email-based aftercare program following inpatient psychotherapy. Principal-components analysis of the most frequently used nouns in the e-mails yielded nine components: life decisions and coping, relationship conflict, psychological and physical symptoms, family of origin, social and leisure activities, present family and household, treatment, exercise and diet, and work. Relative to men, women focused more on symptoms, exercise and diet, and family of origin, but less on work. Older participants were more likely to e-mail about their present family. Younger participants were more likely to e-mail about their family of origin and exercise and diet. Patients who showed no therapeutic gains during their prior treatment wrote more about symptoms than patients who had improved. The potentials and limitations of the MEM for the analysis of therapy corpora are discussed.
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Nat Genet
January 2025
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Malaga/CIBERNED/IBIMA, Málaga, Spain.
Background: Alzheimer's Disease (AD) is a neurodegenerative proteinopathy in which Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. These amyloid aggregation and propagation processes are influenced by three factors: the origin of the Aβ seed, time of incubation and host. However, the mechanism underlying the differential effect of each factor is poorly known.
View Article and Find Full Text PDFNatl Health Stat Report
November 2024
Objective: This report presents national estimates of the percentage of adults age 65 and older who met the federal physical activity guidelines for both aerobic and muscle-strengthening activities during leisure time by sociodemographic and health-related characteristics.
Methods: Data from the 2022 National Health Interview Survey were used to estimate the percentage of adults age 65 and older who met the U.S.
Alzheimers Dement
December 2024
Memory & Aging Center, Department of Neurology, University of California in San Francisco, San Francisco, CA, USA.
Background: Lewy body disease (LBD) often co-occurs with Alzheimer's (AD), resulting in more significant cognitive decline than AD or LBD alone. LBD's hallmarks, asyn-positive Lewy bodies and neurites, propagate from the enteric system or olfactory bulb to the amygdala, which acts as a gatekeeper for spread to other structures. Initially, LBD appears in the central or cortical nuclei, reflecting brainstem or olfactory origins.
View Article and Find Full Text PDFGigaByte
December 2024
Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829, Köln, Germany.
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