AI Article Synopsis
- Characterized interactions between 20 strains of Neisseria meningitidis and immobilized human plasma fibronectin demonstrated that adhesion does not rely on the serogroup.
- Non-piliated strains showed significantly higher adhesion to fibronectin compared to piliated strains, suggesting a complex relationship between pili presence and adhesion ability.
- The study highlights the potential implications of meningococcal adhesion to fibronectin in the context of meningococcal infections and their pathogenesis.
Article Abstract
We have characterized an interaction of 20 strains of Neisseria meningitidis serogroups A, B, C, 29E, W-135 and Z with immobilized fibronectin of human plasma. The adhesion of meningococci to fibronectin was determined by the extent of piliated cells and did not depend on the meningococcal serogroup. Binding of non-piliated or weakly piliated strains (2-5% of piliated cells in the stock) was sufficiently greater than those piliated (8-10%), where the adhesion to fibronectin was not at all observed. The examination of two well-piliated strains showed that the loss of pili resulted in the increase of bacterial adhesion to fibronectin. Constants of association and dissociation of piliated and non-piliated strains to fibronectin were calculated. The role of meningococci-fibronectin interaction in the pathogenesis of meningococcal infection is discussed.
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