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Assessment of heat-killed expressing Chikungunya virus E2 protein as a candidate vaccine for dual protection against Chikungunya virus and .
Front Immunol
January 2025
Nanobioscience Group, Agharkar Research Institute, Pune, India.
The Chikungunya virus (CHIKV) is a mosquito-borne virus with a long history of recurring epidemics transmitted through mosquitoes. The rapid spread of CHIKV has intensified the need for potent vaccines. Escherichia coli (), a vital part of human gut microbiota, is utilized in recombinant DNA technology for cloning.
View Article and Find Full Text PDFCombatting Salmonella: a focus on antimicrobial resistance and the need for effective vaccination.
BMC Infect Dis
January 2025
Division of Animal Biotechnology, Faculty of Veterinary Sciences & Animal Husbandry, SKUAST Kashmir, Shuhama, J&K, 190006, India.
Background: Salmonella infections represent a major global public health concern due to their widespread zoonotic transmission, antimicrobial resistance, and associated morbidity and mortality. This review aimed to summarize the zoonotic nature of Salmonella, the challenges posed by antimicrobial resistance, the global burden of infections, and the need for effective vaccination strategies to mitigate the rising threat of Salmonella.
Methods: A systematic review of literature was conducted using databases such as PubMed, Scopus, Web of Science, and Google Scholar.
Ritonavir enhances the efficacy of amprenavir: A promising combination therapy by targeting Leishmania DNA topoisomerase I for treatment of visceral leishmaniasis.
Exp Parasitol
January 2025
Department of Biotechnology, Savitribai Phule Pune University, 411007, Pune, India. Electronic address:
Visceral leishmaniasis (VL) is an opportunistic infection in HIV patients with higher relapse and mortality rate. The number of HIV-VL patients is comparatively higher in areas where both infections are endemic. However, the conventional chemotherapeutic agents have limited success due to drug toxicity, efficacy variance and overall cost of treatment.
View Article and Find Full Text PDFFunctional response of two Mesocomys species on factitious host Antheraea pernyi and their biocontrol potential against the Japanese giant silkworm Caligula japonica.
Pest Manag Sci
January 2025
State Key Laboratory of Green Pesticides; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.
Background: The Japanese giant silkworm (JGS) Caligula japonica is a significant defoliator pest in East Asia, causing severe economic losses in forest and fruit production. To establish a cost-effective biological control program against JGS, the age-stage, two-sex life table method was used to accurately assess the potential efficacy of two Mesocomys species (M. albitarsis and M.
View Article and Find Full Text PDFFragmented markets for older antibiotics and child formulations, Denmark, Norway, Sweden.
Bull World Health Organ
January 2025
Public Health Agency of Sweden, Solna, Sweden.
Antibiotic resistance is one of the most urgent threats to public health. The development of antibiotic resistance can be reduced by the use of narrow-spectrum antibiotics that target specific bacteria, meaning that fewer non-harmful bacteria are killed and other harmful bacteria are not exposed to selection pressure. However, many narrow-spectrum antibiotics were introduced decades ago and therefore lack regulatory documentation in line with current standards.
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