Homologous recombination and dynamics of rhizobial genomes.

Res Microbiol

Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Michoacan, Ciudad Universitaria, Edificio A1', C.P. 58030, Mexico.

Published: December 2009

The nitrogen-fixing bacteria commonly known as rhizobia are attractive organisms due to their symbiotic association with legume plants. Their genomes contain a large number of redundant genetic elements. These reiterations might participate in homologous recombination events and lead to diverse genomic rearrangements. Here we analyze the role of homologous recombination in the dynamics of these bacterial genomes, as well as its possible biological consequences.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.resmic.2009.09.011DOI Listing

Publication Analysis

Top Keywords

homologous recombination
12
recombination dynamics
8
dynamics rhizobial
4
rhizobial genomes
4
genomes nitrogen-fixing
4
nitrogen-fixing bacteria
4
bacteria commonly
4
commonly rhizobia
4
rhizobia attractive
4
attractive organisms
4

Similar Publications

Broad repression of DNA repair genes in senescent cells identified by integration of transcriptomic data.

Nucleic Acids Res

December 2024

The David and Inez Myers Laboratory for Cancer Research,  Tel Aviv University, Tel Aviv 6997801, Israel.

Cellular senescence plays a significant role in tissue aging. Senescent cells, which resist apoptosis while remaining metabolically active, generate endogenous DNA-damaging agents, primarily reactive oxygen species. Efficient DNA repair is therefore crucial in these cells, especially when they undergo senescence escape, resuming DNA replication and cellular proliferation.

View Article and Find Full Text PDF

The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells.

Proc Natl Acad Sci U S A

January 2025

Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, Department of Biochemistry and Molecular Biology, College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, China.

Poly(ADP-ribose) polymerase 1 (PARP1) plays a crucial role in DNA repair and genomic stability maintenance. However, the regulatory mechanisms governing PARP1 activity, particularly through deubiquitination, remain poorly elucidated. Using a deubiquitinase (DUB) library binding screen, we identified cylindromatosis (CYLD) as a bona fide DUB for PARP1 in breast cancer cells.

View Article and Find Full Text PDF

RAD51 and RAD50 genetic polymorphisms from homologous recombination repair pathway are associated with disease outcomes and organ toxicities in AML.

Blood Res

December 2024

Division of Laboratory Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Meshkin Fam Street, P.O. Box, Shiraz, 71345-1744, Iran.

Background: Acute myeloid leukemia (AML) is a heterogeneous malignancy that responds to various therapies. The sensitivity of leukemia cells to chemotherapy is affected by the DNA damage response (DDR). In this study, we examined the association between RAD51 rs1801320, XRCC3 rs861539, NBS1 rs1805794, MRE11 rs569143, and RAD50 rs2299014 variants of the homologous recombination repair (HRR) pathway and AML outcomes.

View Article and Find Full Text PDF

Chromosomal instability (CIN) is common in solid tumours and fuels evolutionary adaptation and poor prognosis by increasing intratumour heterogeneity. Systematic characterization of driver events in the TRACERx non-small-cell lung cancer (NSCLC) cohort identified that genetic alterations in six genes, including FAT1, result in homologous recombination (HR) repair deficiencies and CIN. Using orthogonal genetic and experimental approaches, we demonstrate that FAT1 alterations are positively selected before genome doubling and associated with HR deficiency.

View Article and Find Full Text PDF

CHAMP1 premature termination codon mutations found in individuals with intellectual disability cause a homologous recombination defect through haploinsufficiency.

Sci Rep

December 2024

Department of Molecular Oncology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

CHAMP1 (chromosome alignment-maintaining phosphoprotein 1) plays a role in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). The CHAMP1 gene is one of the genes mutated in individuals with intellectual disability. The majority of the mutations are premature termination codon (PTC) mutations, while missense mutations have also been reported.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!