Compounds 4a-f, 5a-f and 6-9, showed significant growth inhibition activity against human tumor cell lines. Of these compounds, 1-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one (8) displayed the most potent growth inhibition activity. Compound 8 also arrested cancer cells in G2/M phase and induced apoptosis via activation of caspase-3 and -9. According to western-blotting analysis, compound 8 can up-regulate Bax, down-regulate Bcl-2 and XIAP, as well as promote cytochrome c release.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmc.2009.09.042 | DOI Listing |
Publication Analysis
Top Keywords
growth inhibition
8
inhibition activity
8
1-2-z-6-2-trifluoromethylphenylhexa-3-en-15-diynylphenylpiperidin-2-one potent
4
potent apoptosis
4
apoptosis agent
4
agent compounds
4
compounds 4a-f
4
4a-f 5a-f
4
5a-f 6-9
4
6-9 growth
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!