The last decades have witnessed an increasing interest in psychological aspects of chronic skin disease. Psoriasis has received much attention, partly due to the pivotal change brought to therapeutic concepts by biologics. This article aims to provide a brief overview, with no claims on exhaustiveness, on recent (i.e. stemming from the last 10-15 years) publications on psychodermatological research in psoriasis, with particular reference to those results that have shown in the past or may show in the near future important consequences for clinical practice (i.e. patient education models, psychotropic effects of TNF-alpha antagonists and others). Some considerations are presented on the difficulties encountered on performing clinical studies of non pharmacological interventions. The possible beneficial effect of e-Health projects is discussed.
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Australas J Dermatol
January 2025
King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.
Palmoplantar pustular psoriasis (PPPP), or palmoplantar pustulosis (PPP), is a type of psoriasis that affects the skin on the palms and soles. It is characterised by dermatosis and small sterile pustules and is considered a significant burden on patients' quality of life, as there is currently no gold standard treatment or cure. This network meta-analysis (NMA) compares the efficacy and safety of biologic and non-biologic medications for PPPP and PPP.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Jiangxi Medical College, Nanchang University, Nanchang, China.
Multiple studies have suggested that psoriasis may increase the risk of atrial fibrillation (AF). However, the molecular and immune mechanisms underlying this association remain unclear. This study initially downloaded gene expression profiles for psoriasis and AF from the Gene Expression Omnibus database.
View Article and Find Full Text PDFClin Exp Dermatol
January 2025
Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy.
Background: Guselkumab has been shown to be safe and effective for the treatment of psoriasis in numerous randomized clinical trials and real-life studies. Real life data on treatment up to 4 years are lacking.
Objectives: The present study aims to estimate the drug survival DS, effectiveness, and safety of guselkumab over a period of 208 weeks (w).
Arch Dermatol Res
January 2025
Department of Respiratory Diseases, Erciyes University Medical School, Kayseri, Turkey.
Background/aim: Psoriasis and Hidradenitis Suppurativa (HS) are chronic inflammatory skin conditions that significantly impact quality of life, sleep, and increase morbidity. This study aims to compare sleep quality and the risk of obstructive sleep apnea (OSA) in patients with these conditions. Additionally, it explores the relationships between sleep disorders, demographic factors, disease severity, and inflammatory markers.
View Article and Find Full Text PDFImmunol Res
January 2025
Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
Psoriasis is a chronic, immune-mediated disease. The systemic inflammation triggered by psoriasis contributes significantly to increased cardiovascular risk. While various treatments completely clear the skin, the associated effects on systemic inflammation are not yet clear.
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