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| http://dx.doi.org/10.1111/j.1365-2796.2009.02089.x | DOI Listing |
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METTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell.
J Mol Cell Biol
January 2025
Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
The development and homeostasis of intestinal epithelium are mediated by actively proliferating Lgr5+ stem cells, which possess a remarkable self-renewal and differentiation capacity. Recently, our study demonstrated that m6A methylation was essential for the survival of colonic stem cells. Here, we show that METTL3 expression is downregulated in the colon mucosa in ulcerative colitis (UC) patients and strongly associated with the differentiation and maturation of goblet cells during inflammation.
View Article and Find Full Text PDFInsight Into Body Size Evolution in Aves: Based on Some Body Size-Related Genes.
Integr Zool
December 2024
Institute of Eastern-Himalaya Biodiversity Research, Dali University, Dali, Yunnan, China.
Article Synopsis
- Birds vary greatly in size, making them key for studying how evolution adapts traits like body size, but the genetic factors involved are still not well understood.
- This study examined 15 genes linked to body size in birds, showing notable adaptive evolution in these genes across different bird lineages, especially highlighting the IGF2BP1 gene's connection to larger body sizes.
- The research uncovered distinct evolutionary patterns and convergent evolution in genes associated with body size, providing new insights into the genetic mechanisms driving size adaptations in birds.
Enrichment of trimethyl histone 3 lysine 4 in the Dlk1 and Grb10 genes affects pregnancy outcomes due to dietary manipulation of excess folic acid and low vitamin B12.
Biol Res
November 2024
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
The aberrant expression of placental imprinted genes due to epigenetic alterations during pregnancy can impact fetal development. We investigated the impact of dietary modification of low vitamin B12 with varying doses of folic acid on the epigenetic control of imprinted genes and fetal development using a transgenerational model of C57BL/6J mice. The animals were kept on four distinct dietary combinations based on low vitamin B12 levels and modulated folic acid, mated in the F0 generation within each group.
View Article and Find Full Text PDFComparative population genomics analysis for chicken body sizes using genome-wide SNPs.
Anim Biosci
October 2024
College of Animal Science and Technology, Henan Agricultural University, Zhengzhou, 450046, China.
Objective: This study aims to investigate the selection history, genome regions, and candidate genes associated with different chicken body sizes, thereby providing insights into the genetic basis of complex economic traits such as chicken body size and growth.
Methods: In this study, a total of 217 individuals from eight breeds were selected. According to body size, they were divided into two groups: large chickens and bantam chickens, with four breeds in each group.
Combination of arsenic trioxide and apatinib synergistically inhibits small cell lung cancer by down-regulating VEGFR2/mTOR and Akt/c-Myc signaling pathway via GRB10.
Hereditas
September 2024
Harbin Medical University, Harbin, Heilongjiang Province, China.
Background: Small cell lung carcinoma (SCLC) is characterized by -poor prognosis, -high predilection for -metastasis, -proliferation, and -absence of newer therapeutic options. Elucidation of newer pathways characterizing the disease may allow for development of targeted therapies and consequently favorable outcomes.
Methods: The current study explored the combinatorial action of arsenic trioxide (ATO) and apatinib (APA) in vitro and in vivo.
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