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Introduction: Dercum's disease, also known as adiposis dolorosa, is a rare syndrome characterized by the growth of multiple, and painful, subcutaneous adipose tissues that commonly present in the abdomen and extremities. The scientific community hypothesizes that Dercum's disease is a combination of neurologic and endocrine disorders. Patients commonly describe it as chronic adipose pain, which manifests as sporadic painful flares throughout their history with the disease.

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Lipomatoses.

Ann Endocrinol (Paris)

June 2024

CHU Lille, Endocrinology, Diabetology and Metabolism, 59000 Lille, France; University Lille, 59000 Lille, France; Inserm U1190, 59000 Lille, France; Competence center PRISIS, Endocrinology and Metabolism Department, CHU, Lille, France. Electronic address:

Article Synopsis
  • * These conditions can arise in people without obesity, may have genetic links, and usually differ from lipodystrophy syndromes, which involve areas of fat loss.
  • * The review discusses various forms of lipomatosis, including isolated conditions like Madelung disease and syndromic forms associated with genetic disorders, and highlights their potential impact on health and appearance.
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Dercum's Disease: A Rare Disease of Painful Fatty Lumps.

Cureus

November 2023

Department of Dermatology, Farwaniya Hospital, Ministry of Health, Sabah Al Nasser, KWT.

Dercum's disease is a rare and poorly understood condition characterized by painful subcutaneous adipose tissue growth that can occur anywhere beneath the skin surface. We present the case of a 27-year-old man with no significant medical history who had been experiencing painful subcutaneous nodules for two years. Skin biopsy revealed the proliferation of mature adipocytes that were surrounded by fibrous septa.

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Femoral canal lipoma presenting as chronic venous insufficiency.

J Vasc Surg Cases Innov Tech

September 2023

Department of Vascular Surgery, Hollywood Private Hospital, Nedlands, Western Australia.

Lower limb venous obstruction secondary to a lipoma is a rare occurrence. Patients with these benign soft tissue tumors can be asymptomatic, or may experience symptoms of pain, parasthesia, paralysis and swelling secondary to compression on adjacent neurovascular structures. Duplex ultrasound examination is the first-line investigation, but has its limitations.

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