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Current perspectives on the dynamic culture of mesenchymal stromal/stem cell spheroids.
Stem Cells Transl Med
December 2024
Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Mesenchymal stromal/stem cells (MSCs) are promising candidates for regenerative medicine owing to their self-renewal properties, multilineage differentiation, immunomodulatory effects, and angiogenic potential. MSC spheroids fabricated by 3D culture have recently shown enhanced therapeutic potential. MSC spheroids create a specialized niche with tight cell-cell and cell-extracellular matrix interactions, optimizing their cellular function by mimicking the in vivo environment.
View Article and Find Full Text PDFThe Impact of Bariatric Surgery on Type 2 Diabetes Mellitus Remission: A Systematic Review.
Cureus
November 2024
General Surgery, Salmaniya Medical Complex, Manama, BHR.
Bariatric surgery has been shown to significantly affect type 2 diabetes mellitus (T2DM) remission, particularly in obese individuals. This systematic review aims to evaluate the effectiveness of bariatric surgical interventions in inducing remission of T2DM as well as to identify factors influencing surgical outcomes. The systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
View Article and Find Full Text PDFPharmacists as independent prescribers in community pharmacy: A scoping review.
Res Social Adm Pharm
December 2024
Pharmaceutical Care Research Group, University of Granada, Granada, Spain.
Background: There has been a growing interest in granting prescribing rights to pharmacists as a strategy to improve healthcare access. Researchers continue to explore the impact and implementation of pharmacist prescribing. Given the recent international changes in this field, an overview of current territories allowing pharmacist independent prescribing would provide a comprehensive understanding for researchers and policymakers.
View Article and Find Full Text PDFClinical effects of pediatric commercial food-based formulas: A systematic review.
J Pediatr Gastroenterol Nutr
December 2024
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Blenderized tube feeding (BTF) uses a feeding tube to deliver blended whole foods directly to the gastrointestinal (GI) system and has had renewed interest over the last two decades. This was initially delivered in the form of homemade BTF (HBTF) and led to the development of commercial food-based formula (CFBF). The safety and clinical outcome data for CFBF are limited.
View Article and Find Full Text PDFManagement of Horizontal Cleavage Meniscus Tears.
Curr Rev Musculoskelet Med
December 2024
Department of Orthopaedics, The Ohio State University Wexner Medical Center, 2835 Fred Taylor Dr. Suite 2200, Columbus, OH, 43202, USA.
Purpose Of Review: The management of horizontal cleavage meniscus tears (HCT) has evolved in recent years. Historically, HCTs have been treated with partial meniscectomy, but multiple studies have shown the long-term risks of development of arthritic changes in the knee following meniscectomy. These findings have renewed interest in meniscal preservation whenever possible, even in older patients not previously considered for meniscus repair.
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