The mitotic spindle is mostly perceived as a symmetric structure. However, in many cell divisions, the two poles of the spindle organize asters with different dynamics, associate with different biomolecules or subcellular domains, and perform different functions. In this chapter, we describe some of the most prominent examples of spindle asymmetry. These are encountered during cell-cycle progression in budding and fission yeast and during asymmetric cell divisions of stem cells and embryos. We analyze the molecular mechanisms that lead to generation of spindle asymmetry and discuss the importance of spindle-pole differentiation for the correct outcome of cell division.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S1937-6448(09)78004-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Time-Lapse Imaging of Asymmetric Spindle Positioning During Endothelial Tip Cell Division in Angiogenesis In Vivo.
Methods Mol Biol
December 2024
Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Article Synopsis
- Angiogenesis, the process of forming new blood vessels, is essential for tissue growth and repair, and is often disrupted in various diseases.
- The movement of endothelial cells during angiogenesis is coordinated by asymmetric divisions of tip cells, leading to daughter cells with different sizes and behaviors, crucial for effective blood vessel formation.
- A novel method for live-imaging mitotic spindle positioning in endothelial cells of developing zebrafish embryos allows for detailed observation of spindle dynamics, applicable to other tissues that undergo similar asymmetric divisions.
Solitary Fibrous Tumor of the Mandible.
Head Neck Pathol
November 2024
Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Av. Professor Rodolpho Paulo Rocco, 325, 1º andar, Rio de Janeiro, 21941- 913, Brazil.
A 41-year-old woman presented with a facial asymmetry in the mental region and a painful, well-circumscribed, tender mass in the right lower buccal vestibule, associated with extensive ill-defined bone rarefaction with subtle cortical bone resorption. Microscopically, a proliferation of bland spindle cells interspersed with collagen fibers and prominent staghorn-like blood vessels was observed. Immunohistochemical analysis revealed strong positivity for CD34, Bcl-2, CD99, and STAT-6, confirming the diagnosis of Solitary Fibrous Tumor (SFT).
View Article and Find Full Text PDFStudy on Temperature Response of Rubberized Concrete Pavement Based on Fiber Bragg Grating Testing Technology.
Sensors (Basel)
August 2024
School of Civil Engineering, Yantai University, Yantai 264005, China.
The temperature response of pavement is not only crucial for assessing the internal stresses within pavement structures but is also an essential parameter in pavement design. Investigating the temperature response of rubberized concrete pavements (RCP) can support the construction of large-scale rubber concrete pavements. This study constructed a pavement monitoring system based on fiber Bragg grating technology to investigate the temperature distribution, temperature strain, temperature effects, and temperature stress of RCP.
View Article and Find Full Text PDFSpatial distribution of maternal factors in pig mature oocytes.
Anim Biotechnol
November 2024
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
It is known that asymmetrical maternal transcripts play an important role in the cell fate of the early embryo, but few studies are available in mammal oocytes especially in pig. To investigate the spatial factors in pig oocytes, the oriented bisection was established for collecting karyoplasts (NSOs) and cytoplasts (SSOs) with more than 95% efficiency. Subsequently, RNA-Seq and LC-MS/MS analysis were performed on NSOs and SSOs.
View Article and Find Full Text PDFCentrosome age breaks spindle size symmetry even in cells thought to divide symmetrically.
J Cell Biol
August 2024
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Article Synopsis
- - Centrosomes are key structures in animal cells that organize microtubules, and their age can create differences in spindle lengths during cell division.
- - In human epithelial and fibroblastic cells, older centrosomes lead to slight asymmetries in spindle formation, resulting in uneven daughter cell sizes.
- - This spindle asymmetry is linked to a specific kinase (Plk1) and various proteins that accumulate more on older centrosomes, enhancing their ability to nucleate microtubules, which disrupts expected symmetry in cell division.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!