Objective: The purpose of this pilot trial was to determine whether rates of contact dermatitis following cutaneous antisepsis for central catheter placement were similar among neonates treated with chlorhexidine gluconate and povidone-iodine. Chlorhexidine gluconate absorption was also evaluated.
Study Design: Infants weighing > or =1500 g and > or =7 days of age were randomized to a 10% povidone-iodine or 2% chlorhexidine gluconate site scrub before catheter placement. Primary outcomes evaluated included dermatitis, catheter colonization and chlorhexidine gluconate absorption.
Result: A total of 48 neonates were enrolled. Colonization rates were similar among treatment groups (P<0.6). Dermatitis did not occur at chlorhexidine gluconate (central catheters, n=24; peripheral catheters, n=29) sites. Seven neonates had measurable chlorhexidine gluconate concentrations (range 13 to 100 ng ml(-1)) during catheterization.
Conclusion: In this small trial chlorhexidine gluconate antisepsis was tolerated by study neonates. Chlorhexidine gluconate was cutaneously absorbed. Larger trials are needed to determine efficacy and tolerance of chlorhexidine gluconate in neonates.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/jp.2009.161 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Use of chlorhexidine digluconate 7.1% gel for umbilical cord care in selected regions in Northern Ghana: qualitative perspectives of key stakeholders.
BMC Pregnancy Childbirth
December 2024
School of Public Health, University of Ghana, P.O. Box LG 25, Legon, Accra, Ghana.
Background: The Government of Ghana in 2017 included chlorhexidine (CHX) digluconate 7.1% gel in the essential medicines list to replace methylated spirit for umbilical cord care. However, there are limited studies around the use of the CHX gel.
View Article and Find Full Text PDFAlcohol-based antisepsis without the use of chlorhexidine for arthroscopy in horses.
J Equine Vet Sci
December 2024
Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave, Charlottetown Prince Edward Island, Canada C1A 4P3. Electronic address:
Alcohol-based antisepsis has shown experimentally to be as effective as 4 % chlorhexidine gluconate (CHG) at reducing bacterial counts (colony forming units; CFU) on equine skin. Our objectives were to determine the immediate and post-surgical reduction in CFU/mL on equine skin prepared with CHG-based or 70 % isopropyl alcohol (IPA)-based (without CHG) protocols in a clinical setting with arthroscopic surgery. Our hypotheses were that the logCFU/mL reduction would not significantly differ between protocols immediately after preparation or at the end of surgery.
View Article and Find Full Text PDFEvaluation of the effects of Andiz extract on the experimentally wound in rats by microbiological and gene expression methods.
Mol Biol Rep
December 2024
Department of Aquaculture, Faculty of Aquaculture, Van YüzüncüYıl University, Van, Turkey.
Objectives: This study aimed to investigate the effects of andiz extract on wound healing and compare it with saline and chlorhexidine gluconate. Microbial DNA load was used to evaluate its antibacterial effects, and gene expression methods were used to assess its contribution to cytokine release and wound healing.
Methods And Results: A standardized wound site was created with a 3 mm diameter punch on 32 male Wistar albino rats.
The Effect of Using Chlorhexidine Gluconate and Povidone Iodine Solution on the Healing Process Before a Cesarean Section.
J Perianesth Nurs
December 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
Purpose: This study aimed to compare the effect of povidone iodine (PI) and chlorhexidine gluconate (CG) shower groups on the healing process in cesarean section operations.
Design: Randomized controlled trial.
Methods: Patients were recruited from Gynecology and Obstetrics Hospital in Turkey between February and May 2021.
Purpose: The purpose of this laboratory study was to evaluate common materials for isolation and neutralizing agents for hydrofluoric acid (HF). Additionally, surfaces of lithium disilicate ceramic were examined for precipitates after the etching and neutralizing process.
Materials And Methods: The HF permeability of the following isolation agents (n=8) was investigated by positioning them over pH indicator paper under airtight conditions and applying 9% HF: latex rubber dam; elastic plastomer rubber dam; nitrile gloves; latex gloves; liquid rubber dam; Teflon; AZ strip.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!