Objective: The purpose of this study was to describe the frequencies and relationships of non-specific non-essential diagnostic criteria and non-CNS organ system injury in term intra-partum asphyxia.

Methods: All children with term intra-partum asphyxia encountered in a single pediatric neurology practice with at least two years follow-up and an abnormal neurologic outcome were identified.

Results: A total of 40 children (28 males, 12 females) were identified. Twenty-four had moderate NE and sixteen severe NE. The mean number of non-specific non-essential diagnostic criteria (out of a possible 7) was 4.75+/-1.39 SD. Sixty percent had five or more criteria and all criteria were present in only 10% of newborns. The mean number of non-CNS organ systems affected was 2.88+/-1.96 SD (out of a possible 6). Ten percent of our sample showed no evident non-CNS organ injury acutely.

Conclusion: Most asphyxiated neonates failed to consistently satisfy all elements of present consensus statements.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpn.2009.09.002DOI Listing

Publication Analysis

Top Keywords

non-cns organ
16
term intra-partum
12
intra-partum asphyxia
8
criteria non-cns
8
organ injury
8
non-specific non-essential
8
non-essential diagnostic
8
diagnostic criteria
8
criteria
5
asphyxia analysis
4

Similar Publications

Glioblastoma (GBM) is an aggressive primary brain tumor depicted by a cold tumor microenvironment, low immunogenicity, and limited effective therapeutic interventions. Its location in the brain, a highly immune-selective organ, acts as a barrier, limiting immune access and promoting GBM dissemination, despite therapeutic interventions. Currently, chemotherapy and radiation combined with surgical resection are the standard of care for GBM treatment.

View Article and Find Full Text PDF

Treating metastatic malignancies to the central nervous system (CNS) is challenging because many drugs cannot cross the blood-brain-barrier (BBB). Direct intrathecal (IT) drug administration into the cerebrospinal fluid (CSF) is a strategy to overcome this problem. Thiotepa has effective CNS penetration but its popularity has waned over the last two decades due to concerns about its efficacy and potential systemic toxicity.

View Article and Find Full Text PDF

Distinct roles of TREM2 in central nervous system cancers and peripheral cancers.

Cancer Cell

June 2024

Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China. Electronic address:

Glioblastomas (GBM) are incurable central nervous system (CNS) cancers characterized by substantial myeloid cell infiltration. Whether myeloid cell-directed therapeutic targets identified in peripheral non-CNS cancers are applicable to GBM requires further study. Here, we identify that the critical immunosuppressive target in peripheral cancers, triggering receptor expressed on myeloid cells-2 (TREM2), is immunoprotective in GBM.

View Article and Find Full Text PDF
Article Synopsis
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) can affect multiple organs, including skin and bone marrow, with different patterns observed in 66 patients at diagnosis categorized by types of involvement.
  • Patients categorizing with "skin only" BPDCN were generally older and showed fewer genetic mutations compared to those with systemic involvement, who experienced less UV exposure.
  • Overall survival rates varied significantly based on organ involvement, with better outcomes for patients without overt bone marrow involvement, highlighting the importance of disease characteristics and genetics for prognosis and future research.
View Article and Find Full Text PDF

Background: This study aimed to compare the ultrasound (USG) and fetal magnetic resonance imaging (MRI) findings in the evaluation of congenital fetal anomalies and to determine whether the management is changes significantly if MRI is combined with USG.

Methods: In this prospective observational cohort study, we performed fetal MRI in 90 consecutive cases of fetuses diagnosed or suspected as having congenital anomalies on a prior level II USG scan. We then compared the USG and MRI findings of each anomaly according to the diagnostic information yielded by each modality.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!