AI Article Synopsis
- - The study investigates the blood pressure-lowering effects of Chamaemelum nobile aqueous extract (CNAE) in spontaneously hypertensive rats (SHRs).
- - A single dose of CNAE (140 mg/kg) resulted in a significant drop in systolic blood pressure after 24 hours, and continued daily doses led to sustained reductions starting from day 8 of treatment.
- - CNAE also increased urinary output and electrolyte excretion, confirming its hypotensive and diuretic properties in the test subjects.
Article Abstract
This study aims to evaluate the hypotensive effect of Chamaemelum nobile aqueous extract (CNAE) in spontaneously hypertensive rats (SHRs). Single oral administration of CNAE (140 mg/kg) produced a significant reduction (p < 0.05) in systolic blood pressure (SBP) after 24 h of the administration. Daily oral administration of CNAE (140 mg/kg) during 3 weeks produced a significant reduction in SBP in the day 8 (p < 0.01) of treatment. Furthermore, CNAE produced a significant increase in urinary output and electrolytes excretion (p < 0.01) from the day 8 to the end of treatment. We conclude that CNAE possesses a hypotensive and diuretic effect in SHR.
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| http://dx.doi.org/10.1080/10641960902825453 | DOI Listing |
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Hypotensive effect of Chamaemelum nobile aqueous extract in spontaneously hypertensive rats.
Clin Exp Hypertens
July 2009
UFRPNPE B. P., Errachidia, Morocco.
Article Synopsis
- - The study investigates the blood pressure-lowering effects of Chamaemelum nobile aqueous extract (CNAE) in spontaneously hypertensive rats (SHRs).
- - A single dose of CNAE (140 mg/kg) resulted in a significant drop in systolic blood pressure after 24 hours, and continued daily doses led to sustained reductions starting from day 8 of treatment.
- - CNAE also increased urinary output and electrolyte excretion, confirming its hypotensive and diuretic properties in the test subjects.
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