AI Article Synopsis
- A range of medicinal chemistry techniques can help find potential drug candidates and speed up their development.
- The Emory Chemical and Biology Discovery Center is involved in high-throughput screening to discover effective small molecule probes for lesser-known proteins, focusing on cancer and viral infections.
- Three notable projects include discovering inhibitors for measles virus, developing blockers for Heat Shock Protein 90, and finding angiogenesis inhibitors using transgenic Zebrafish for screening.
Article Abstract
A variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads and to accelerate the development of drug candidates. The Emory Chemical and Biology Discovery Center (ECBDC) has been an active participant in the NIH's high-throughput screening (HTS) endeavor to identify potent small molecule probes for poorly studied proteins. Several of Emory's projects relate to cancer or virus infection. We have chosen three successful examples including discovery of potent measles virus RNA-dependent RNA polymerase inhibitors, development of Heat Shock Protein 90 (Hsp90) blockers and identification of angiogenesis inhibitors using transgenic Zebrafish as a HTS model. In parallel with HTS, a unique component of the Emory virtual screening (VS) effort, namely, substructure enrichment analysis (SEA) program has been utilized in several cases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442615 | PMC |
| http://dx.doi.org/10.2174/156802609789753581 | DOI Listing |
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