Total synthesis of amphidinolide Q.

Org Lett

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

Published: November 2009

Asymmetric synthesis of amphidinolide Q, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp., has been accomplished with Julia coupling, Myers alkylation, and Yamaguchi lactonization. The absolute configuration of amphidinolide Q was confirmed to be 1 from comparison of the NMR data and [alpha](D) values of synthetic and natural amphidinolide Q.

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol902026fDOI Listing

Publication Analysis

Top Keywords

synthesis amphidinolide
8
total synthesis
4
amphidinolide
4
amphidinolide asymmetric
4
asymmetric synthesis
4
amphidinolide cytotoxic
4
cytotoxic macrolide
4
macrolide cultured
4
cultured dinoflagellate
4
dinoflagellate amphidinium
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!