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Examination of the interaction of parameters for low-intensity focused ultrasound of the human motor cortex.
Brain Stimul
December 2024
Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, 24016, USA; Virginia Tech Carilion School of Medicine, Roanoke, VA, 24016, USA; Center for Human Neuroscience Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, 24016, USA; Center for Health Behaviors Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, 24016, USA; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24016, USA; Graduate Program in Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, 24016, USA; Department of Neurosurgery, Carilion Clinic, Roanoke, VA, 24016, USA. Electronic address:
Background: Low-intensity focused ultrasound (LIFU) is a promising form of non-invasive neuromodulation characterized by a rich parameter space that includes intensity, duration, duty cycle and pulsing strategy. The effect and interaction of these parameters to affect human brain activity is poorly understood. A better understanding of how parameters interact is critical to advance LIFU as a potential therapeutic.
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- Mid-infrared optical sources are key for applications like gas sensing and metrology, utilizing molecular absorption in this spectral range.
- Parametric frequency conversion methods, especially continuous-wave (CW)-seeded optical parametric generation (OPG), offer enhanced stability and performance for generating mid-infrared light.
- The proposed femtosecond OPG system in periodically poled lithium niobate waveguides features a high quantum efficiency of 46.5% and is promising for compact mid-infrared combs, aiding in practical uses like environmental monitoring.
Broadband quantum light is a vital resource for quantum metrology and spectroscopy applications such as quantum optical coherence tomography or entangled two photon absorption. For entangled two photon absorption in particular, very high photon flux combined with high time-frequency entanglement is crucial for observing a signal. So far these conditions could be met by using high power lasers driving degenerate, type 0 bulk-crystal spontaneous parametric down conversion (SPDC) sources.
View Article and Find Full Text PDFWhile mid-infrared optical frequency combs have been widely utilized in areas such as trace gas sensing, chemical kinetics, and combustion science, their relatively low power has limited sensitivities and led to correspondingly long acquisition times. We have developed a new approach in which an electro-optic frequency comb is utilized to pump a continuous-wave singly-resonant optical parametric oscillator in order to spectrally translate the comb into the mid-infrared (2.19 µm and 4.
View Article and Find Full Text PDFWe report on a high-energy, few-ps, continuous-wave pumped Ho:YLF regenerative amplifier (RA) operating in a chirped-pulse amplification arrangement. A three-stage optical parametric amplifier serves as versatile seed source emitting broadband pulses centered at 2050 nm. It provides seed pulses with 4 µJ energy within the Ho:YLF amplification bandwidth centered at 2051 nm.
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