Three new flavonoid glycosides (cissosides I, II, and III) and a new benzofuran-type stilbene (cissusin) were isolated from the methanolic extract of the aerial parts of Cissus sicyoides cultivated in Brazil. Their structures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated constituents on the release of beta-hexosaminidase as a marker of degranulation in rat basophilic leukemia (RBL-2H3) cells were examined. Cissusin, flavonols (kaempferol, quercetin), flavones (7,3',4'-trihydroxyflavone, lanceolatin B), pterocarpanes (homopterocarpin), chalcones (isoliquiritigenin, E-7-O-methylpongamol), and tryptanthrin markedly inhibited the release of beta-hexosaminidase.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1248/cpb.57.1089 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Benzofuran Derivatives from Cortex Mori Radicis and Their Cholinesterase-Inhibitory Activity.
Molecules
January 2024
College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou 466001, China.
The phytochemical investigation of Cortex Mori Radicis led to the isolation and identification of a new prenylated benzofuranone () and four ring-opening derivatives (-) named albaphenol A-E, as well as nigranol A (), together with ten 2-arylbenzofuran derivatives (-). The characterization of the structures of the new compounds and the structural revision of nigranol A () were conducted using the comprehensive analysis of spectroscopic data (1D/2D NMR, HRESIMS, CD, and XRD). Compounds - were tested for their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).
View Article and Find Full Text PDFBioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR₁.
Molecules
February 2017
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis. The new compounds were identified as (9)-moracin P 3'--α-l-arabinopyranoside (), (9)-moracin P 9--β-d-glucopyranoside (), (9)-moracin P 3'--β-d-glucopyranoside (), and (9)-moracin O 10--β-d-glucopyranoside () based on the spectroscopic interpretation and chemical analysis. Three benzofuran-type stilbenes, moracin O (), R (), and P () showed significant neuroprotective activity against glutamate-induced cell death in SK-N-SH cells.
View Article and Find Full Text PDFThree new flavonoid glycosides (cissosides I, II, and III) and a new benzofuran-type stilbene (cissusin) were isolated from the methanolic extract of the aerial parts of Cissus sicyoides cultivated in Brazil. Their structures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated constituents on the release of beta-hexosaminidase as a marker of degranulation in rat basophilic leukemia (RBL-2H3) cells were examined.
View Article and Find Full Text PDFDifferentiation-dependent levels of benzofuran-type resveratrol dimers in root cultures of Anigozanthos preissii.
Phytochemistry
September 2003
Max-Planck-Institut für Chemische Okologie, Beutenberg Campus, Winzerlaer Strasse 10, D-07745 Jena, Germany.
The level of secondary compounds formed by sterile root cultures of Anigozanthos preissii depends on the differentiation state. Cultures showing shoot formation and accelerated growth are depleted in stilbenes, stilbene glucosides, and phenylphenalenones. Three glucosides of anigopreissin A, a benzofuran-type resveratrol dimer, were isolated from slow-growing cultures and their structures elucidated by spectrometric methods.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!