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Anxiety-depressive disorders (ADD) have a negative impact on the course and prognosis of patients with ischemic heart disease, but the mechanisms of their correlation are not studied enough. The purpose of this study was to elucidate special characteristics of hemostasis and immune system in patients with acute coronary syndrome (ACS) combined with ADD. We included into the study 60 patients during first 24 hours of ACS.

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[The State of Hemostasis and Immune System in Patients With Acute Coronary Syndrome Combined With Anxiety-Depressive Disorder].

Kardiologiia

August 2015

1 Prof. V.F. Vojno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia; 2Municipal Budget Health Agency Clinical Emergency Hospital named N.S. Karpovicha Krasnoyarsk, Russia; 3Scientific Research Institute of Medical problems of the North of Academy of Medical Sciences Krasnoyarsk, Russia.

Anxiety-depressive disorders (DD) have a negative impact on the course and prognosis of patients with ischemic heart disease, but the mechanisms of their correlation are not studied enough. The purpose of this study was to elucidate special characteristics of hemostasis and immune system in patients with acute coronary syndrome (ACS) combined with ADD. We included into the study 60 patients during first 24 hours of ACS.

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Vascular complications of arterial hypertension are known to depend not only on the hypertension level, but also on risk factors including also dyslipoproteinemia and disorders of vascular and platelet hemostasis. Therefore studies of early mechanisms underlying arterial hypertension in medical staffers are topical and serve as a basis for early prevention of cardiovascular complications.

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Saliva of bloodsuckers (leeches, insects, ticks, vampire bats) contains various regulators of some hemostatic stages. This review summarizes information on their structural characteristics and mechanisms of action. Most bloodsuckers are shown to inhibit vascular-platelet hemostasis by blocking collagen-induced platelet adhesion/aggregation.

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