Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cphc.200900435 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Methodology to identify subject-specific dynamic laxity tests to stretch individual parts of knee ligaments.
Med Eng Phys
November 2024
Department of Materials and Production, Center for Mathematical Modeling of Knee Osteoarthritis, Aalborg University, Fibigerstræde 16, 9220 Aalborg East, Denmark. Electronic address:
The mechanical properties of ligaments are important for multiple applications and are often estimated from laxity tests. However, the typical laxity tests are not optimized for this application and, a potential exists to develop better laxity tests in this respect. Therefore, the purpose of this study was to develop a methodology to identify optimal, dynamic laxity tests that isolate the stretch of the individual ligaments from each other.
View Article and Find Full Text PDFForce-velocity-power variables derived from isometric and dynamic testing: metrics reliability and the relationship with jump performance.
PeerJ
November 2024
Faculty of Physical Education and Sport, Charles University in Prague, Prague, Czech Republic.
We investigated the convergent validity and intrasession reliability of force, velocity, and power (FVP) variables and the dynamic strength index (DSI) obtained from isometric midthigh pull (IMTP) and squat jump (SJ) testing. Fifteen male combat sports athletes (27 ± 5 years, 77 ± 9 kg, 1.76 ± 0.
View Article and Find Full Text PDFStacking correlation length in single-stranded DNA.
Nucleic Acids Res
November 2024
Small Biosystems Lab, Departament de Física de la Matèria Condensada, Facultat de Física, Universitat de Barcelona, Carrer de Martí i Franquès, 1, 08028 Barcelona, Spain.
Base stacking is crucial in nucleic acid stabilization, from DNA duplex hybridization to single-stranded DNA (ssDNA) protein binding. While stacking energies are tiny in ssDNA, they are inextricably mixed with hydrogen bonding in DNA base pairing, making their measurement challenging. We conduct unzipping experiments with optical tweezers of short poly-purine (dA and alternating dG and dA) sequences of 20-40 bases.
View Article and Find Full Text PDFSingle-molecule force spectroscopy of toehold-mediated strand displacement.
Nat Commun
August 2024
Technical University of Munich, TUM School of Natural Sciences, Department of Bioscience, Center for Functional Protein Assemblies (CPA), Garching, Germany.
Toehold-mediated strand displacement (TMSD) is extensively utilized in dynamic DNA nanotechnology and for a wide range of DNA or RNA-based reaction circuits. Investigation of TMSD kinetics typically relies on bulk fluorescence measurements providing effective, bulk-averaged reaction rates. Information on individual molecules or even base pairs is scarce.
View Article and Find Full Text PDFUnfolding rates of 1:1 and 2:1 complex of CX-5461 and c- promoter G-quadruplexes revealed by single-molecule force spectroscopy.
Biophys Rep
June 2024
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
CX-5461, also known as pidnarulex, is a strong G4 stabilizer and has received FDA fast-track designation for BRCA1- and BRCA2- mutated cancers. However, quantitative measurements of the unfolding rates of CX-5461-G4 complexes which are important for the regulation function of G4s, remain lacking. Here, we employ single-molecule magnetic tweezers to measure the unfolding force distributions of c- G4s in the presence of different concentrations of CX-5461.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!