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Fondation Pierre-Gilles de Gennes pour la Recherche, c/o LBPA, Ecole Normale Supérieure de Cachan, 61 Avenue de Président Wilson, 94235 Cachan Cedex, France.
Published: December 2009
AI Article Synopsis
Nucleosomes are like spools around which DNA wraps, and where they sit on the DNA helps control how genes work.
Nucleosomes that are near important parts of genes tend to be more precisely placed than those farther away.
Different studies might show different results because they use different methods to look at nucleosomes on the same DNA, especially near the beginning of genes in a type of yeast.
Article Abstract
The positioning of nucleosomes on the DNA of eukaryotic genomes is a major determinant of gene expression. In particular nucleosomes in close proximity to regulatory regions are often more precisely positioned in vivo than nucleosomes located elsewhere. In this article we compare data obtained from the most recent studies by a variety of techniques. We argue that the disparate conclusions in the literature could be a consequence of procedural differences sampling alternative arrays of nucleosomes on the same DNA sequence. Importantly, the ostensibly least invasive techniques identify differences between nucleosomes in the vicinity of transcription start sites in budding yeast and those positioned distally within the transcribed region.
