The purpose of this study was to determine the effectiveness of antihistamine therapy for withdrawal movements caused by rocuronium injection. One hundred seventy one ASA I-II adults undergoing elective surgery were randomly assigned to one of two groups. Patients in the control group (Group C) were premedicated with 2 mL normal saline, and those in the antihistamine group (Group A) were pre-medicated with 2 mL (45.5 mg) pheniramine maleate. After the administration of thiopental sodium 5 mg/kg, rocuronium 0.6 mg/kg was injected. Withdrawal movements were assessed using a four-grade scale. The administration of antihistamine reveals lower grade of withdrawal movement after rocuronium injection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752772 | PMC |
| http://dx.doi.org/10.3346/jkms.2009.24.5.879 | DOI Listing |
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Article Synopsis
- General anaesthesia is essential for quick and precise tracheal intubation, often using neuromuscular blocking drugs like rocuronium and cisatracurium to maintain oxygen levels and stable blood pressure during the procedure.
- A study aimed to compare the effectiveness and onset of action of these two muscle relaxants in providing optimal conditions for intubation while monitoring their side effects and overall stability.
- Results showed that rocuronium allowed for favorable intubating conditions much faster (within 90 seconds) compared to cisatracurium (240 seconds), with both groups exhibiting similar haemodynamic stability.
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