Paraneoplastic limbic encephalitis cured with resection of an adnexal mass.

JSLS

Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, 46202, USA.

Published: November 2009

AI Article Synopsis

  • Paraneoplastic syndromes involve various health issues linked to cancers, such as adnexal masses, leading to complications like limbic encephalitis.
  • A case is presented where a female patient experienced severe symptoms like confusion and aggression due to paraneoplastic limbic encephalitis, which improved after surgical removal of a mature teratoma.
  • It's crucial for women showing limbic encephalitis symptoms to be screened for tumors, as timely intervention can significantly improve outcomes.

Article Abstract

Background: Paraneoplastic syndromes are a heterogeneous collection of disease manifestations caused by underlying neoplasms, which can include adnexal masses.

Case: We report a case of paraneoplastic limbic encephalitis consisting of confusion, agitation, and aggression, which subsequently progressed to a comatose state, in the presence of an adnexal mass. It was cured with resection of a mature teratoma with focal immature components.

Conclusion: Female patients who present with symptoms of limbic encephalitis should be thoroughly screened for malignancy. Gynecologic consultation is an important component of the diagnostic workup when an adnexal mass has been identified. Paraneoplastic limbic encephalitis is a serious condition, yet it has a good prognosis if treated promptly with surgical resection of the adnexal mass.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015981PMC

Publication Analysis

Top Keywords

limbic encephalitis
16
adnexal mass
16
paraneoplastic limbic
12
cured resection
8
resection adnexal
8
adnexal
5
paraneoplastic
4
encephalitis
4
encephalitis cured
4
mass
4

Similar Publications

Background And Objectives: Cognitive deficits represent a major long-term complication of anti-leucine-rich, glioma-inactivated 1 encephalitis (LGI1-E). Although severely affecting patient outcomes, the structural brain changes underlying these deficits remain poorly understood. In this study, we hypothesized a link between white matter (WM) networks and cognitive outcomes in LGI1-E.

View Article and Find Full Text PDF

Anti-NMDA (N-methyl-D-aspartate) receptor encephalitis (ANRE) is a rare autoimmune condition targeting brain receptors, often linked to ovarian tumors in young women. In severe cases, it can lead to status epilepticus, but in sporadic cases, it may progress to super-refractory status epilepticus (SRSE), a dangerous state of continuous or repetitive seizures demanding urgent medical attention that continues or recurs more than 24 hours after the initiation of anesthetic therapy. We present a case report of anti-NMDA receptor limbic encephalitis-triggered SRSE terminated with vagus nerve stimulation (VNS) and titrated to high stimulation parameters in the immediate postoperative period.

View Article and Find Full Text PDF

A Rare Case of Anti-Caspr2 Autoimmune Encephalitis Associated with a Testicular Mixed Germ Cell Tumor.

J Community Hosp Intern Med Perspect

November 2024

Department of Internal Medicine, HCA Healthcare, MountainView Hospital, 2880 N Tenaya Way, 89128, Las Vegas, NV, USA.

Paraneoplastic limbic encephalitis (PLE) is a poorly understood condition, thought to be caused by the cross-reacting of tumor antibodies with neurons in the brain, resulting in neuropsychiatric sequelae, such as personality and behavioral changes, psychosis, memory loss, and seizures. Anti-contactin-associated protein-like 2 (CASPR2) antibodies can cause PLE in patients with particular tumors, which in most cases can be identified as thymoma, lung cancer, or endometrial cancer. Some case reports show rare instances with other tumors, such as throat or sigmoid carcinoma.

View Article and Find Full Text PDF

We aimed to define the clinical features and outcomes of encephalitis associated with anti-GAD65 Abs. In addition, we reviewed cases published in the literature with GAD65 encephalitis. We retrospectively studied 482 consecutive patients attending a tertiary care center for evaluation of an autoimmune neurological disorder.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!